Type IV collagen levels are elevated in the serum of patients with peritoneal dissemination of gastric cancer
Type IV collagen levels are elevated in the serum of patients with peritoneal dissemination of gastric cancer
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DOI：
10.3892/ol.2010.181
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发表时间：
2010-11-01
期刊：
影响因子：
2.9
通讯作者：
Ohta, Tetsuo
中科院分区：
文献类型：
--
作者：
Kinoshita, Jun;Fushida, Sachio;Ohta, Tetsuo
III型前胶原（III型前胶原的氨基末端前肽）和IV型胶原被认为是监测肝纤维化进展的可靠血清标志物。胃癌腹膜转移的特征还在于腹膜中大量胶原沉积。本研究旨在探讨胃癌III型前胶原和IV型胶原作为胃癌腹膜转移生物标志物的可能性。研究人群包括117例胃癌患者：32例患者经剖腹手术或腹腔镜检查病理诊断为腹膜播散，而85例患者（45/40，早期/晚期胃癌）无腹膜播散。我们测量了III型前胶原和IV型胶原的血清水平，并与公认的肿瘤标记物癌胚抗原（CEA）、碳水化合物抗原（CA）19-9和CA 125进行比较。III型前胶原水平的中位数在两组之间无显著差异，而IV型胶原水平的中位数在有腹膜转移的患者中显著高于无腹膜转移的患者（早期/进展期胃癌，124/136 ng/ml）（P
Type III procollagen (amino-terminal propeptide of procollagen type III) and type IV collagen are considered to be reliable serum markers for monitoring the progression of liver fibrosis. The peritoneal dissemination of gastric cancer is also characterised by abundant collagen deposition in the peritoneum. The present study was performed to investigate the potential of scrum type III procollagen and IV collagen as biomarkers for peritoneal dissemination in gastric cancer. The study population consisted of 117 patients with gastric cancer: 32 patients had peritoneal dissemination which was pathologically diagnosed by laparotomy or laparoscopic examination, while 85 patients (45/40, early/advanced gastric cancer) had no peritoneal dissemination. We measured the serum levels of type III procollagen and type IV collagen in comparison to the commonly accepted tumor markers carcinoembryonic (CEA), carbohydrate antigen (CA)19-9 and CA125. The median type III procollagen levels showed no significant differences between the two groups, whereas the median type IV collagen levels were significantly (201 ng/ml) higher in patients with than in those without peritoneal dissemination (early/advanced gastric cancer, 124/136 ng/ml) (P