Effectiveness of atypical antipsychotics for substance use in schizophrenia patients.
Effectiveness of atypical antipsychotics for substance use in schizophrenia patients.
复制标题
非典型抗精神病药对精神分裂症患者物质使用的有效性。
DOI：
10.1016/j.schres.2007.05.007
复制
发表时间：
2007
影响因子：
4.5
通讯作者：
Swartz,MarvinS
中科院分区：
文献类型：
--
作者：
Swanson,Jeffrey;VanDorn,RichardA;Swartz,MarvinS
CAPTIVEThis study examined the impact of medicine class（nonspecific antipsychotic，typical antipsychotic and no medicine）and compliance on substance use outcomes for schizophrenia patients in the community.METHODN=362 adults with schizophrenia-spectrum disorder were followed for 3 years in a naturalistic study with structured interviews at 6-months intervals.多变量时间序列分析采用倾向评分调整选择药物类别。在每6个月内依从非典型抗精神病药物治疗90天或更长时间的参与者在接下来的6个月内使用药物的可能性显著降低。与那些依从典型抗精神病药物或未开具任何类型药物至少90个月的患者相比，结论非典型抗精神病药物在减少精神分裂症患者的物质使用方面可能具有优势。为了使患者从非典型抗精神病药物中获益，治疗应侧重于提高依从性和整合物质使用治疗。
OBJECTIVEThis study examined the influence of medication class (atypical antipsychotic, typical antipsychotic and no medication) and compliance on substance use outcomes for schizophrenia patients in the community.METHODN=362 adults with schizophrenia-spectrum disorder were followed for 3 years in a naturalistic study with structured interviews at 6-month intervals. Multivariable time-series analysis was performed using propensity-score adjustment for selection to medication class.RESULTSParticipants who were compliant with atypical antipsychotic medications for 90 days or more during each 6-month period were significantly less likely to use substances during the next 6-month period than patients who were compliant with typical antipsychotics or those who were not prescribed either type of medication for at least 90 days.CONCLUSIONAtypical antipsychotics may offer an advantage in reducing substance use among schizophrenia patients. For patients to benefit from atypical antipsychotics, treatment should focus on enhancing compliance and integrating substance use treatment.