Nailfold capillary morphology in exfoliation syndrome
Nailfold capillary morphology in exfoliation syndrome
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DOI：
10.1038/eye.2016.312
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发表时间：
2017-05-01
期刊：
影响因子：
3.9
通讯作者：
Pasquale, L. R.
中科院分区：
文献类型：
--
作者：
Cousins, C. C.;Kang, J. H.;Pasquale, L. R.
目的-这项研究的目的是探讨甲襞微血管形态剥脱综合征或无青光眼（XFS/XFG）与原发性开角型青光眼（POAG）和对照组相比，使用甲襞毛细血管videomicroscopy.Patients和方法我们使用了JH-1004毛细血管镜进行甲襞毛细血管videomicroscopy. Patients和第四和第五数字的非优势手。我们招募了56名XFS/XFG患者，87名POAG患者和75名对照受试者。戴面具的观察者对视频进行分级，包括血管扩张、>= 200微米（μ m）的无血管区和微血管迂曲程度（4分主观量表）。多变量比值比，95%置信区间和P-趋势，以评估形态学变化和POAG或XFS/XFG之间的关系，从逻辑回归分析。结果在调整多个协变量后，XFS/XFG组与对照组相比，甲襞扩张、无血管区>= 200 μ m和血管迂曲度更常见（P <0.05
Purpose The purpose of the study was to investigate nailfold microvascular morphology in exfoliation syndrome with or without glaucoma (XFS/XFG) compared with primary open-angle glaucoma (POAG) and control subjects using nailfold capillary videomicroscopy.Patients and methods We used a JH-1004 capillaroscope to perform nailfold capillary videomicroscopy on the fourth and fifth digit of the non-dominant hand. We enrolled 56 XFS/XFG patients, 87 POAG patients, and 75 control subjects. Masked observers graded the videos for hemorrhages, avascular zones >= 200 microns (mu m), and degree of microvascular tortuosity on a four-point subjective scale. Multivariable odds ratios, 95% confidence intervals and P-for trends for assessing the relation between morphological changes and POAG or XFS/XFG were obtained from logistic regression analyses. We also assessed this relation with XFS/XFG compared with POAG in multivariable models.Results After adjusting for multiple covariates, nailfold hemorrhages, avascular zones >= 200 mu m, and higher degree of vascular tortuosity were more common in XFS/XFG vs controls (P-for trend