Importance of Tight Junctions in Relation to Skin Barrier Function
Importance of Tight Junctions in Relation to Skin Barrier Function
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DOI：
10.1159/000441541
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发表时间：
2016-01-01
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影响因子：
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通讯作者：
Brandner, Johanna M.
中科院分区：
文献类型：
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作者：
Brandner, Johanna M.
紧密连接(TJ)是哺乳动物皮肤颗粒层中形成屏障的复杂的细胞-细胞连接。除了形成屏障外，TJ还影响其他皮肤屏障，例如角质层屏障，并受到其他皮肤屏障的影响，例如化学物质、微生物组或免疫屏障，并可能受到基底膜的影响。本文综述了TJ屏障与皮肤中其他屏障的动态相互作用以及TJ在皮肤屏障功能中的中心作用。(C)2016年S.Karger AG，巴塞尔
Tight junctions (TJs) are complex cell- cell junctions that form a barrier in the stratum granulosum of mammalian skin. Besides forming a barrier themselves, TJs influence other skin barriers, e. g. the stratum corneum barrier, and are influenced by other skin barriers, e. g. by the chemical, the microbiome, or the immunological barrier and likely by the basement membrane. This review summarizes the dynamic interaction of the TJ barrier with other barriers in the skin and the central role of TJs in skin barrier function. (C) 2016 S. Karger AG, Basel