Rationale of Mesenchymal Stem Cell Therapy in Kidney Injury
Rationale of Mesenchymal Stem Cell Therapy in Kidney Injury
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DOI：
10.1053/j.ajkd.2012.05.027
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发表时间：
2013-02-01
影响因子：
13.2
通讯作者：
Camussi, Giovanni
中科院分区：
文献类型：
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作者：
Cantaluppi, Vincenzo;Biancone, Luigi;Camussi, Giovanni
大量的临床前和临床研究表明，间充质干细胞，也称为多能间充质基质细胞（MSC），可以改善涉及不同器官的病理条件。这些有益的效果最初归因于MSC分化为器官实质细胞。然而，至少在肾脏中，这是非常罕见的事件，MSC的肾脏保护作用主要归因于旁分泌机制。骨髓间充质干细胞释放许多营养，抗炎和免疫调节因子，可能限制肾损伤和有利于恢复。在这篇文章中，我们提供了一个概述间充质干细胞的生物活性，可能是相关的治疗肾损伤的情况下，小插曲的背景下，关于患者在高免疫风险谁经历了第二次肾移植，然后发展缺血再灌注损伤和急性同种异体排斥反应。我们讨论了可能的有益效果，MSC治疗的光的临床前和临床数据支持的再生和免疫调节潜力的MSC。美国肾脏病杂志，61（2）：300-309。(c)2013年，美国国家肾脏基金会（National Kidney Foundation，Inc.）
Numerous preclinical and clinical studies suggest that mesenchymal stem cells, also known as multipotent mesenchymal stromal cells (MSCs), may improve pathologic conditions involving different organs. These beneficial effects initially were ascribed to the differentiation of MSCs into organ parenchymal cells. However, at least in the kidney, this is a very rare event and the kidney-protective effects of MSCs have been attributed mainly to paracrine mechanisms. MSCs release a number of trophic, anti-inflammatory, and immune-modulatory factors that may limit kidney injury and favor recovery. In this article, we provide an overview of the biologic activities of MSCs that may be relevant for the treatment of kidney injury in the context of a case vignette concerning a patient at high immunologic risk who underwent a second kidney transplantation followed by the development of ischemia-reperfusion injury and acute allograft rejection. We discuss the possible beneficial effect of MSC treatment in the light of preclinical and clinical data supporting the regenerative and immunomodulatory potential of MSCs. Am J Kidney Dis. 61(2):300-309. (c) 2013 by the National Kidney Foundation, Inc.