Plasma advanced glycation end-products and skin autofluorescence are increased in COPD
Plasma advanced glycation end-products and skin autofluorescence are increased in COPD
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DOI：
10.1183/09031936.00135312
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发表时间：
2014-02-01
影响因子：
24.3
通讯作者：
Rutten, Erica P. A.
中科院分区：
文献类型：
--
作者：
Gopal, Poornima;Reynaert, Niki L.;Rutten, Erica P. A.
慢性阻塞性肺疾病（COPD）与全身炎症和氧化应激有关。本研究对88例COPD患者和55例对照者进行了糖基化终末产物（AGEs）的检测（80%的戒烟者）血浆蛋白结合AGEs N-末端-N-末端-（羧甲基）赖氨酸（CML）、戊糖苷、N-乙酰-（羧乙基）赖氨酸（GEL），和通过皮肤自发荧光（AFR）测定的皮肤中的AGE积累，平均+/- SD血浆CML降低（COPD 61.6 +/- 15.6 nmol.mmol（-1）赖氨酸，从不吸烟者80.7 +/- 19.8 nmol.mmol（-1）赖氨酸，既往吸烟者82.9 +/- 19.3 nmol. mmol（-1）赖氨酸）和GEL（COPD 39.1 +/- 10.9 nmol. mmol（-1）赖氨酸，从不吸烟者30.4 +/- 5.0 nmol.mmol（-1）赖氨酸，既往吸烟者27.7 +/- 6.4 nmol.mmol（-1）赖氨酸）和APR与对照组相比，COPD患者中COPD 3.33 +/- 0.67任意单位（Au）、从不吸烟者2.24 +/- 0.45 Au和戒烟者2.31 +/- 0.47 Au增加。疾病状态与CML呈负相关，与CEL和AFR呈线性相关。在总组中进行回归分析，CEL和AFR与肺功能呈负相关，CML与肺功能呈正相关，即使校正了潜在的混杂因素。在总组中，只有AGEs与1 s用力呼气量相关。我们的数据表明，AGEs参与了COPD的病理生理学，虽然他们的确切作用仍有待确定。
Chronic obstructive pulmonary disease (COPD) is associated with systemic inflammation and oxidative stress. These conditions may lead to the formation of advanced glycation end-products (AGEs).In this study we investigated in 88 COPD patients and 55 control subjects (80% ex-smokers) the association of the plasma protein-bound AGEs N-epsilon-(carboxymethyl)lysine (CML), pentosidine, N-epsilon-(carboxyethyl)lysine (GEL), and AGE accumulation in skin by skin autofluorescence (AFR), with lung function.Mean +/- SD plasma CML was decreased (COPD 61.6 +/- 15.6 nmol.mmol(-1) lysine, never-smokers 80.7 +/- 19.8 nmol.mmol(-1) lysine and ex-smokers 82.9 +/- 19.3 nmol-mmol(-1) lysine) and GEL (COPD 39.1 +/- 10.9 nmol-mmol(-1) lysine, never-smokers 30.4 +/- 5.0 nmol.mmol(-1) lysine and ex-smokers 27.7 +/- 6.4 nmol.mmol(-1) lysine) and APR (COPD 3.33 +/- 0.67 arbitrary units (AU), never-smokers 2.24 +/- 0.45 AU and ex-smokers 2.31 +/- 0.47 AU) were increased in COPD patients compared to controls. Disease state was inversely associated with CML, and linearly associated with CEL and AFR. Performing regression analyses in the total group, CEL and AFR showed a negative association and CML a positive association with lung function, even after correction for potential confounders.In conclusion, GEL and AFR were negatively and CML was positively associated with disease state. In the total group only the AGEs showed an association with forced expiratory volume in 1 s. Our data suggest that AGEs are involved in the pathophysiology of COPD, although their exact role remains to be determined.