Strategy for discriminating cholesterol and premalignancy in polypoid lesions of the gallbladder: a single-centre, retrospective cohort study
Strategy for discriminating cholesterol and premalignancy in polypoid lesions of the gallbladder: a single-centre, retrospective cohort study
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区分胆囊息肉样病变中胆固醇和癌前病变的策略：单中心回顾性队列研究
DOI：
10.1111/ans.14961
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发表时间：
2019-04-01
影响因子：
1.7
通讯作者：
Yan, Sheng
中科院分区：
文献类型：
--
作者：
Wu, Tianchun;Sun, Zhongquan;Yan, Sheng
背景本研究旨在评估胆囊息肉样病变（PLGs）中胆固醇和癌前病变的危险因素，并建立适当的治疗策略。结果共纳入1561例患者。该队列包括636例（40.7%）男性和925例（59.3%）女性，平均年龄为49.5岁（范围16-88）;该队列中65.6%（1024/1561）显示胆固醇病变，其中胆固醇息肉占81.0%。年龄小于50岁和息肉多发是胆固醇病变的独立预测变量（OR = 3.461，95%可信区间（CI）2.058-5.820，P
BackgroundThe present study aimed to assess the risk factors of cholesterol and premalignancy in polypoid lesions of the gallbladder (PLGs) and to establish an appropriate treatment strategy.MethodsData from patients who underwent cholecystectomy at the First Affiliated Hospital, School of Medicine, Zhejiang University, between January 2011 and July 2017, were collected retrospectively.ResultsA total of 1561 patients were included in the present study. The cohort comprised of 636 (40.7%) males and 925 (59.3%) females, with a mean age of 49.5 (range 16-88) years; 65.6% (1024/1561) demonstrated cholesterol lesions in this cohort, among which cholesterol polyps accounted for 81.0%. Age younger than 50years and multiple number of polyps were found to be independent predictive variables for cholesterol lesions (odds ratio (OR) 3.461, 95% confidence interval (CI) 2.058-5.820, P