A nano-delivery system for bioactive ingredients using supercritical carbon dioxide and its release behaviors
A nano-delivery system for bioactive ingredients using supercritical carbon dioxide and its release behaviors
复制标题
超临界二氧化碳生物活性成分纳米递送系统及其释放行为
DOI：
10.1016/j.foodchem.2017.01.053
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发表时间：
2017-08-01
期刊：
影响因子：
8.8
通讯作者：
Liang, Yan
中科院分区：
文献类型：
--
作者：
Situ, Wenbei;Song, Xianliang;Liang, Yan
为了保证生物活性成分的生物利用度，利用超临界二氧化碳（SC-CO2）开发了一种低毒的纳米给药系统。与薄膜水合法（TFH）相比，使用SC-CO2更容易获得纳米级脂质体。通过对脂质体粒径和形态的分析，证实了脂质体的特性。体外释放研究表明，使用SC-CO2生产的脂质体在模拟胃条件下对低pH值具有耐受性。在模拟肠道环境中，这些脂质体的肠溶度增加，这是控制释放生物活性成分的重要特性。此外，SC-CO2产生的脂质体具有比使用TFH产生的脂质体更高的储存稳定性。用气相色谱-质谱联用仪（GC-MS）分析脂质体中有机溶剂残留量，结果表明SC-CO2法制备的脂质体毒性低于TFH法制备的脂质体。使用SC-CO2的无化学品纳米递送系统已被揭示用于生物活性成分的储存和控制释放。(C)2017爱思唯尔有限公司版权所有
For the purpose of ensuring the bioavailability of bioactive ingredients, a nano-delivery system with low toxicity was developed using supercritical carbon dioxide (SC-CO2). Compared to thin-film hydration (TFH), obtaining nano-scale liposomes is easier using SC-CO2. The characteristic of these liposomes was also demonstrated by the analysis of particle size and morphology. An in vitro release study showed that liposomes produced using SC-CO2 were resistant to low pH in simulated gastric conditions. In a simulated intestinal environment, enteric solubility of these liposomes was enhanced, which are important properties for controlled releasing bioactive ingredient. Furthermore, SC-CO2-produced liposomes had a higher storage stability than those produced using TFH. Analysis of the organic solvent residue in the liposomes by gas chromatography-mass spectrometry (GC-MS) indicated that SC-CO2-produced liposomes had lower toxicity than those produced by TFH. A chemical free nano-delivery system using SC-CO2 has been revealed for storage and controlled release of bioactive ingredients. (C) 2017 Elsevier Ltd. All rights reserved.