High prevalence of molecular markers for resistance to chloroquine and pyrimethamine in Plasmodium falciparum from Zimbabwe.
High prevalence of molecular markers for resistance to chloroquine and pyrimethamine in Plasmodium falciparum from Zimbabwe.
复制标题
津巴布韦恶性疟原虫中氯喹和乙胺嘧啶耐药分子标记的流行率很高。
DOI：
10.1007/s00436-007-0597-5
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发表时间：
2007
影响因子：
2
通讯作者：
Kumar,Nirbhay
中科院分区：
文献类型：
--
作者：
Mlambo,Godfree;Sullivan,David;Mutambu,SusanL;Soko,White;Mbedzi,Joel;Chivenga,James;Gemperli,Armin;Kumar,Nirbhay
Chloroquine has been the first line drug of treatment for malaria in Zimbabwe until a recent adoption of an interim policy to treat using a combination of chloroquine (CQ) and sulfadoxine/pyrimethamine (SP). We examined the prevalence of parasites with mutations associated with resistance to the drug combination in three areas that have been previously described to differ in malaria endemicity. Our results show that the parasite population from the three areas had a high prevalence of molecular markers of resistance to chloroquine and pyrimethamine. The prevalence ofcrt(K76T) was 64, 82, and 92% for Chiredzi, Kariba, and Bindura, respectively. On thedhfrlocus, the presence of triple mutations (codons 51, 59, and 108) was approximately 50% for all the three locations. On the other hand, the prevalence ofdhpsmutations (codons 436, 437, and 540) was low accounting for less than 20% in all the areas. Studies reported here demonstrate widespread prevalence of molecular markers associated with chloroquine and pyrimethamine resistance and should be taken into consideration for further refinement of malaria control strategies in Zimbabwe. The design and implementation of successful control strategies would benefit from understanding the prevalence of mutations associated with drug resistance in parasite populations.
