Black phosphorus-polypyrrole nanocomposites for high-performance photothermal cancer therapy
Black phosphorus-polypyrrole nanocomposites for high-performance photothermal cancer therapy
复制标题
用于高性能光热癌症治疗的黑磷-聚吡咯纳米复合材料
DOI：
10.1039/c9nj01249d
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发表时间：
2019
影响因子：
3.3
通讯作者：
Zhiming Liu
中科院分区：
文献类型：
--
作者：
Chengkang Su;Huiqing Zhong;Haolin Chen;Yanxian Guo;Zhouyi Guo;Deqiu Huang;Wen Zhang;Qiang Wu;Biwen Yang;Zhiming Liu
黑磷（BP）具有良好的生物相容性、生物可降解性和在紫外至近红外（NIR）波段的宽带吸收特性，是新一代二维纳米材料，具有光热治疗（PTT）的巨大潜力。然而，由于BP在近红外区域的光吸收减少，在BP基近红外PTT中，需要适当而不是低剂量的纳米剂来达到满意的治疗效果。在本研究中，利用BP纳米片和若干聚吡咯（PPy）纳米颗粒（BP/PPy NSs）的叠加近红外吸收特性，制备了高性能近红外PTT的纳米杂化体。纳米复合材料具有不规则、斑点状和片状的形态，具有良好的生物相容性和较好的近红外光热转导效率。利用BP/PPy NSs作为新型纳米治疗剂在体外和体内进行了近红外光热肿瘤强化治疗。
The favorable biocompatibility, biodegradability and broadband absorption in the ultraviolet to near-infrared (NIR) region have made black phosphorus (BP) a new generation two-dimensional nanomaterial with great potential for photothermal therapy (PTT). However, an appropriate but not low dosage of nanoagent is required to achieve the satisfactory therapeutic effect in BP-based NIR PTT, due to the decreasing light absorption of BP in the NIR region. In this work, nanohybrids composed of BP nanosheets and several polypyrrole (PPy) nanoparticles attached to them (BP/PPy NSs) are fabricated for high-performance NIR PTT, benefiting from the superimposed NIR absorption characteristics of the two components. The nanocomposites exhibit irregular, speckled and flake-like morphologies with good biocompatibility and superior NIR photothermal transduction efficiency compared with that of the bare nanosheets. The utilization of BP/PPy NSs as novel nanotherapeutic agent for enhanced NIR photothermal cancer therapy is accomplished in vitro and in vivo.