Human metapneumovirus associated with respiratory tract infections in a 3-year study of nasal swabs from infants in Italy
Human metapneumovirus associated with respiratory tract infections in a 3-year study of nasal swabs from infants in Italy
复制标题
DOI：
10.1128/jcm.41.7.2987-2991.2003
复制
发表时间：
2003-07-01
影响因子：
9.4
通讯作者：
Bendinelli, M
中科院分区：
文献类型：
--
作者：
Maggi, F;Pifferi, M;Bendinelli, M
据报道，新近发现的人类偏肺病毒(HMPV)更常与下呼吸道疾病有关。本研究检查了意大利比萨90名患有急性呼吸道感染的婴儿的鼻拭子样本，时间跨度为三个呼吸道病毒季节。3年间感染发生率不同，2001年hMPV阳性率为7%，2000年和2002年分别为37%和43%。HMPV按典型的呼吸道合胞病毒发生频率的模式季节性发生。在感染hMPV的婴儿中，超过一半(14/23)患有支气管炎。三分之一(9/23)的hMPV感染患者还感染了另一种呼吸道病毒，这种关系以前从未报道过。与单独感染hMPV相比，混合感染在支气管肺炎病例中所占比例并不高。此外，在17名同时接受血浆hMPV RNA检测的婴儿中，有7名在鼻拭子和血液样本中均被证实携带病毒。研究表明，hMPV与其他呼吸道病毒一样常见，可能与婴儿严重的呼吸道疾病有关，可与其他呼吸道病毒混合感染，并具有季节性发生。
The newly described human metapneumovirus (hMPV) is reported here to be more commonly associated with lower respiratory tract disease. The present study examined nasal swab specimens from 90 infants with acute respiratory tract infections in Pisa, Italy, over a period of three respiratory virus seasons. The incidence of infection varied in each of the 3 years, with the rates of positivity for hMPV being 7% in 2001 but 37 and 43% in 2000 and 2002, respectively. hMPV was noted to occur seasonally in a pattern typical of the frequency of occurrence of respiratory syncytial virus. More than one-half (14 of 23) of the infants infected with hMPV had bronchopneumonia. One-third (9 of 23) of the hMPV-infected patients were also infected with another respiratory virus, a relationship that has not previously been reported. Mixed infections did not account for a higher percentage of cases of bronchopneumonia than hMPV infection alone did. Furthermore, 7 of 17 infants whose plasma was also tested for hMPV RNA were demonstrated to have virus in both nasal swab and blood specimens. The study indicates that hMPV is seen as commonly as other respiratory viruses, may be associated,with severe respiratory disease in infants, can establish mixed infections with other respiratory viruses, and has a seasonal occurrence.