Correlates of periodic limb movements of sleep in the pediatric population
Correlates of periodic limb movements of sleep in the pediatric population
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DOI：
10.1016/j.pediatrneurol.2008.03.008
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发表时间：
2008-07-01
影响因子：
3.8
通讯作者：
Kothare, Sanjeev V.
中科院分区：
文献类型：
--
作者：
Do, Shaila Bokkala;Napalinga, Katherine;Kothare, Sanjeev V.
儿童睡眠的周期性肢体运动在临床上被低估了。多导睡眠图是最准确的诊断测试。关于儿童多导睡眠监测结果的信息很少。我们评估了多导睡眠图检测到的儿童周期性肢体运动的患病率及其相关性。在982例多导睡眠图中，77例发现有周期性肢体运动，患病率为7.8%，男性居多(47名男孩，30名女孩)。平均年龄9.4±4.2岁(1~19岁)(体重指数24.1±12.3)。平均睡眠时间为395.4±73.4min，其中快速眼动睡眠占16.6%+/-6.7%，慢波睡眠占22%+/-10%。睡眠效率为93.8+/-9.83，周期性肢体运动指数为9.78+/-7.9，周期性肢体运动觉醒指数为4.5+/-8.4，觉醒指数为27.8+/-12.4，呼气末二氧化碳分压峰值为48.9+/-10.5 mm Hg。相关诊断包括阻塞性睡眠呼吸暂停36例(46.8%)，注意缺陷多动障碍10例(13%)，偏头痛7例(9.1%)，癫痫发作7例(9.1%)，孤独症谱系障碍5例(6.5%)，发作性睡病7例(9.1%)。血清铁蛋白下降29例(96.6%)，平均26.1mUg/L。前瞻性研究可能阐明多导睡眠图检测到的儿童睡眠中偶然的周期性肢体运动的意义。(C)2008年，爱思唯尔公司。保留所有权利。
Periodic limb movements of sleep are clinically underdiagnosed in children. Polysomnography is the most accurate diagnostic test. There is a paucity of information regarding polysomnography findings in children. We evaluated the prevalence and correlates of pediatric periodic limb movements detected by polysomnography. Periodic limb movements of sleep were identified in 77 of 982 polysomnograms, with a prevalence of 7.8% and male predominance (47 boys; 30 girls). Mean age was 9.4 +/- 4.2 years (1-19 years) (body mass index, 24.1 +/- 12.3). Mean sleep time was 395.4 +/- 73.4 minutes, of which rapid eye movement sleep constituted 16.6% +/- 6.7%, and slow-wave sleep, 22% +/- 10%. Sleep efficiency was 93.8 +/- 9.83, periodic limb movement index, 9.78 +/- 7.9; periodic limb movement arousal, 4.5 +/- 8.4; arousal index, 27.8 +/- 12.4; and peak end-tidal CO2, 48.9 +/- 10.5 mm Hg. Associated diagnoses included obstructive sleep apnea in 36 (46.8%), attention deficit hyperactivity disorder in 10 (13%), migraine in 7 (9.1%), seizures in 7 (9.1%), autism spectrum disorders in 5 (6.5%), and narcolepsy in 7 (9.1%). Serum ferritin was decreased (mean, 26.1 mu g/L) in 29 (96.6%). Prospective studies may clarify the significance of incidental pediatric periodic limb movements in sleep detected on polysomnograms. (C) 2008 by Elsevier Inc. All rights reserved.