FUNCTIONAL SEX-REVERSED OOCYTE IN MOUSE
FUNCTIONAL SEX-REVERSED OOCYTE IN MOUSE
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DOI：
10.1098/rspb.1975.0086
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
BARNES, RD
中科院分区：
文献类型：
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作者：
FORD, CE;EVANS, EP;BARNES, RD
从近交系小鼠AKR/J和CBA/H-T6中获得的两个可育雌性嵌合体具有混合性染色体XX/XY。两种嵌合体的XY组分均为AKR(白化)。记录显示，其中一只嵌合体总共生了两窝共七只幼崽，其中包括一只穿着白化皮毛的特殊儿子。这意味着母性配子起源于XY成分。对其他可能的解释进行了研究，并有效地排除了这些解释。这个特殊的儿子是不育的，后来被发现具有罕见的41，XXY(‘Klinefelter’)核型。迄今为止，小鼠嵌合体生殖细胞功能逆转的可能性被排除在外，因为它们的后代的性比显然没有受到干扰，而且在试验配对中单表型后代的数量过多。这一证据被重新审查，并被证明对雌性嵌合体是不确定的。
Two fertile female chimaeras derived by aggregation of morulae from the inbred mouse strains AKR/J and CBA/H-T6 were found to be of mixed sex chromosome constitution, XX/XY. The XY component of both chimaeras was AKR (albino). The records showed that one of the chimaeras had two litters totalling seven young including an exceptional son with an albino coat. This implied that the maternal gamete had originated from the XY component. Other possible explanations are examined and effectively excluded. The exceptional son was sterile and was later found to have the rare 41, XXY (‘Klinefelter’) karyotype. The possibility of functional reversal of germ cells in mouse chimaeras had hitherto been dismissed on the basis of the apparently undisturbed sex ratio of their progeny and the great excess of single-phenotype progenies in test matings. This evidence is re-examined and shown to be indecisive for female chimaeras.