Bio-inspired immobilization of low-fouling phospholipid polymers via a simple dipping process: a comparative study of phenol, catechol and gallol as tethering groups
Bio-inspired immobilization of low-fouling phospholipid polymers via a simple dipping process: a comparative study of phenol, catechol and gallol as tethering groups
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DOI：
10.1039/c9py00625g
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发表时间：
2020-01-14
影响因子：
4.6
通讯作者：
Ejima, Hirotaka
中科院分区：
文献类型：
--
作者：
Cheng, Bohan;Ishihara, Kazuhiko;Ejima, Hirotaka
我们报告了一种具有成本效益的合成方法的共聚物含有生物启发酚和磷胆碱基团的侧链。比较了含有儿茶酚、苯酚、苯基或正丁基基团的参比聚合物在表面上的吸附。我们发现，在这些测试中，甘油三酯组是最有效的功能组，可以固定表面上的低污染磷脂聚合物。该胶层具有与市售磷脂聚合物（LIPIDURE (R)-PMB）相同程度的低污垢特性，同时具有更好的耐溶剂性，特别是在水和醇中。因此，我们期望所报道的方法在经常涉及酒精灭菌过程的生物医学应用中是有利的。
We report on a cost-effective synthesis method for copolymers containing bioinspired phenolic and phosphorylcholine groups in the side chain. Adsorption of the gallol group bearing polymers onto surfaces was compared with reference polymers containing catechol, phenol, phenyl or n-butyl groups. We found that the gallol group was the most effective functional group among those tested to immobilize the low-fouling phospholipid polymer on surfaces. The adlayer exhibited the same degree of low-fouling properties as the commercially available phospholipid polymer (LIPIDURE (R)-PMB), while exhibiting better solvent resistance, especially in water and alcohol. Thus we expect that the reported method may be advantageous in biomedical applications that often involve an alcohol sterilization process.