Efficacy of steroid injection on idiopathic sudden sensorineural hearing loss
Efficacy of steroid injection on idiopathic sudden sensorineural hearing loss
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DOI：
10.1016/j.otohns.2006.03.035
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发表时间：
2006-08-01
影响因子：
3.4
通讯作者：
Chang, C. Y. Joseph
中科院分区：
文献类型：
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作者：
Roebuck, Jeremy;Chang, C. Y. Joseph
目的：评价经鼓膜类固醇注射治疗特发性突发性感音神经性听力损失（ISSNHL）患者与单纯口服类固醇治疗患者的疗效。研究设计：回顾性图表回顾。方法：纳入有ISSNHL病史且口服类固醇治疗失败的患者。如果在72小时内发生超过20 dB的SNHL，则进行听音图检查并纳入患者。将接受经鼓膜类固醇注射的患者与单独接受口服类固醇的患者进行比较。结果：61例患者符合纳入标准，纳入研究。注射组平均纯音改善9例（30%），而口服组平均纯音改善5例（17%）。与口服类固醇组仅有3例（10%）相比，注射组有12例（38.7%）患者的言语辨别分数改善超过15%。结论：我们的研究显示，口服类固醇治疗失败的ISSNHL患者与口服类固醇相比，经鼓膜类固醇获得了更好的听力效果。
OBJECTIVE: To evaluate the effectiveness of transtympanic steroid injection on patients with idiopathic sudden sensorineural hearing loss (ISSNHL) compared with patients who receive oral steroids alone.STUDY DESIGN: Retrospective chart review.METHODS: Patients with a history of ISSNHL and failed oral steroid therapy were included. Audiograms were performed and patients were included if SNHL of more than 20 dB occurred over less than 72 hours. Patients who received transtympanic steroid injection were compared with those who received oral steroids alone.RESULTS: Sixty-one patients met inclusion criteria and were included in the study. The number of patients with improvement in pure tone average in the injection group was 9 (30%) compared with 5 (17%) in the oral group. Twelve (38.7%) of the injected patients did have improvement in speech discrimination scores of greater than 15% compared with only 3 (10%) in the oral steroid group.CONCLUSION: Our study revealed that patients with ISSNHL who have failed oral steroid therapy obtain better hearing results with transtympanic steroids in comparison to oral steroids.