Uterine artery blood flow and renal sympathetic nerve activity during exercise in rabbit pregnancy.
Uterine artery blood flow and renal sympathetic nerve activity during exercise in rabbit pregnancy.
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DOI：
10.1152/ajpregu.00258.2003
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发表时间：
2003-11
期刊：
影响因子：
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通讯作者：
K. O’Hagan;J. A. Alberts
中科院分区：
文献类型：
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作者：
K. O’Hagan;J. A. Alberts
在12只未孕（NP）和17只足月妊娠（P）家兔上观察了子宫动脉血流（UtBF）和肾交感神经活动（SNA）对跑台运动的反应。用跨音速流量探头连续监测UtBF。兔子进行了三个运动试验（5分钟持续时间），不同的绝对工作量。肾SNA的升高与运动强度有关。妊娠并不影响相对于最大活性表达的平均稳态肾SNA反应（P 24 +/- 1% vs. NP 23 +/- 2%的最大烟雾引起的活动），并增加相对于静息活动表达的平均肾SNA反应（P +155 +/- 19% vs. NP +84 +/- 23%，与静息时相比，P = 0.03）静息时，UtBF（P 13 +/- 3 vs. NP 1.9 +/- 0.3 ml/min）和子宫动脉传导（UtC; P 22 +/- 5 vs. NP 2.8 +/- 0.5 ml. min-1.mmHg-1 × 10 ~（-2）。在P组家兔中，UtBF（P-16 +/- 4% vs. NP-48 +/- 4%）和UtC（P-27 +/- 4% vs. NP-54 +/- 4%）的平均运动相关降低减弱。妊娠并不损害提高肾SNA的能力，但减弱了兔子宫动脉缩窄肌对中度至重度动态运动的反应。在正常情况下，妊娠子宫循环床可能相对受到保护，不受运动相关血流再分布的影响。
The uterine artery blood flow (UtBF) and renal sympathetic nerve activity (SNA) responses to treadmill exercise were evaluated in 12 nonpregnant (NP) and 17 term pregnant (P) rabbits. UtBF was monitored continuously with a Transonic flowprobe. Rabbits underwent three exercise trials (5-min duration) that varied in absolute workload. The rise in renal SNA with exercise was intensity related. Pregnancy did not affect the average steady-state renal SNA response expressed relative to maximum activity (P 24 +/- 1% vs. NP 23 +/- 2% of maximum smoke-elicited activity) and increased the average renal SNA response expressed relative to resting activity (P +155 +/- 19% vs. NP +84 +/- 23% from rest, P = 0.03) At rest, UtBF (P 13 +/- 3 vs. NP 1.9 +/- 0.3 ml/min) and uterine artery conductance (UtC; P 22 +/- 5 vs. NP 2.8 +/- 0.5 ml. min-1.mmHg-1 x 10-2) were elevated in the P rabbits. The average exercise-related decreases in UtBF (P -16 +/- 4% vs. NP -48 +/- 4%) and UtC (P -27 +/- 4% vs. NP -54 +/- 4%) were attenuated in the P rabbits. Pregnancy does not impair the ability to raise renal SNA but attenuates the uterine artery constrictor response to moderate to heavy dynamic exercise in rabbits. Under normal conditions, the pregnant uterine circulatory bed may be relatively protected from exercise-related redistribution of blood flow.