A phylotypic stage in vertebrate brain development: GABA cell patterns in zebrafish compared with mouse
A phylotypic stage in vertebrate brain development: GABA cell patterns in zebrafish compared with mouse
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DOI：
10.1002/cne.20824
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发表时间：
2006-02-01
影响因子：
2.5
通讯作者：
Wullimann, MF
中科院分区：
文献类型：
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作者：
Mueller, T;Vernier, P;Wullimann, MF
最近对小鼠和斑马鱼早期前脑基因表达的比较揭示了发育相关基因的高度可比性表达模式，例如，在特定时间窗（小鼠：胚胎期12.5/13.5天；斑马鱼：3天）参与神经发生的前神经基因（Neurogenin1, NeuroD, Mash1/Zash1a）。在这里，我们将这一分析扩展到描述胚胎后早期斑马鱼大脑（即早期继发性神经发生期间）的γ -氨基丁酸（GABA）细胞模式。我们再次发现斑马鱼和小鼠之间的GABA细胞模式在先前建立的关键时间窗口中具有惊人的对应程度，例如，关于GABA细胞在某些前脑区域（pallium， thalamus背侧，thalami）的缺失，或者关于GABA细胞的时空发生（例如，小脑晚期GABA细胞）。此外，小鼠和斑马鱼之间存在与先前建立的前脑基因表达模式（即在无gaba细胞的前脑区域缺乏Mash1/Zash1a基因表达）的完全相关。在其他脊椎动物物种，特别是非洲爪蟾中，现有的信息也与我们在这里的分析高度一致，并表明在脊椎动物大脑发育过程中可能存在神经发生的“种型阶段”。
A recent comparison of early forebrain gene expression in mouse and zebrafish revealed highly comparable expression patterns of developmentally relevant genes, for example, of proneural (Neurogenin1, NeuroD, Mash1/Zash1a) genes involved in neurogenesis at a particular time window (mouse: embryonic day 12.5/13.5; zebrafish: 3 days). Here we extend this analysis to the description of gamma-aminobutyric acid (GABA) cell patterns in the early postembryonic zebrafish brain (i.e., during early secondary neurogenesis). We find again an astonishing degree of correspondences of GABA cell patterns between zebrafish and mouse during this previously established critical time window, for example, regarding absence of GABA cells in certain forebrain regions (pallium, dorsal thalamus, eminentia thalami) or with respect to the spatiotemporal occurrence of GABA cells (e.g., late cerebellar GABA cells). Furthermore, there is perfect correlation with previously established proneural gene expression patterns (i.e., absence of Mash1/Zash1a gene expression in GABA-cell-free forebrain regions) between mouse and zebrafish. The available information in additional vertebrate species, especially in Xenopus, is also highly consistent with our analysis here and suggests that a "phylotypic stage" of neurogenesis during vertebrate brain development may be present.