Prolonged Th-2 cell activation and increased viral replication in HIV-Leishmania co-infected patients despite treatment
Prolonged Th-2 cell activation and increased viral replication in HIV-Leishmania co-infected patients despite treatment
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DOI：
10.1016/s0035-9203(96)90538-6
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发表时间：
1996-07-01
影响因子：
2.2
通讯作者：
Doerr, HW
中科院分区：
文献类型：
--
作者：
Cacopardo, B;Nigro, L;Doerr, HW
在一项初步研究中，对意大利的8例内脏利什曼病（VL）患者进行了一系列免疫学和病毒学调查。4例HIV阳性患者中有3例在急性VL发作后8个月内发展为AIDS。所有受试者均存在血清抗利什曼抗体，所有患者均接受了单疗程的锑酸葡甲胺治疗。所有患者的治疗均获得成功。在那些同时感染HIV和利什曼原虫的患者中，血清中Th2细胞因子水平升高，白细胞介素（IL）2和IL 12浓度下降。血清干扰素γ水平也显著升高。血清HIV RNA浓度也在随访期间增加。它的结论是，在合并感染的患者，这些数据似乎表明一个不可逆的开关从1型到2型反应，尽管治疗。这表明，这种现象可能有利于发展为艾滋病。
In a pilot study, serial immunological and virological investigations were made in 8 patients in Italy with visceral leishmaniasis (VL). Three of the 4 patients who were HIV-positive developed AIDS within 8 months from the onset of acute VL. Serum antileishmanial antibodies were present in all subjects and all patients received a single course of meglumine antimonate. Treatment was successful in all patients. In those patients co-infected with HIV andLeishmaniapersistently elevated Th2cytokine levels were demonstrated in serum, together with declining concentrations of interleukin (IL) 2 and IL 12. There were also significant increases in serum levels of interferon γ. Serum HIV RNA concentrations also increased during follow-up. It is concluded that in co-infected patients these data seem to indicate an irreversible switch from type 1 to a type 2 response, in spite of therapy. It is suggested that this phenomenon may favour the progression to AIDS.