Carcinogenesis alters fatty acid profile in breast tissue
Carcinogenesis alters fatty acid profile in breast tissue
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DOI：
10.1007/s11010-012-1523-4
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发表时间：
2013-02-01
影响因子：
4.3
通讯作者：
Moghadasian, Mohammed H.
中科院分区：
文献类型：
--
作者：
Azordegan, Nazila;Fraser, Virginia;Moghadasian, Mohammed H.
癌的发生与细胞膜的变化有关。这项研究的目的是调查不同程度的癌症参与的乳腺组织是否具有不同的脂肪酸谱。招募了14名平均年龄为61岁的乳腺癌患者。肿瘤标本的形态学特征进行了表征。大约60%的患者患有浸润性导管癌，80%为ER阳性; 65%为PR阳性; 65%为HER 2阴性。与相应的大体正常或界面组织相比，确诊为癌症的节段的总脂质量显著减少。癌组织中脂肪酸的组成与其他组织有显著差异。五类磷脂的脂肪酸组成揭示了癌组织与其他两个部分之间的差异。观察到这些磷脂组分中脂肪酸组成变化的过渡。界面组织中含有中等量的几种脂肪酸，包括棕榈酸、硬脂酸和花生四烯酸。有趣的是，我们观察到与其他两种组织相比，癌症组织中的n-3脂肪酸DHA的含量显著较高。本研究的数据将提供证据表明，生化变化，特别是磷脂组成可能会提前发生形态学变化。如果这一理论得到更大规模研究的证实，磷脂组成与正常值的偏差可以用作组织对癌症发展的易感性的标志。
Cancerogenesis is associated with cell membrane changes. The aim of this study was to investigate whether breast tissues with different degrees of cancer involvement have different fatty acid profiles. Fourteen breast cancer patients with a mean age of 61 years were recruited. Morphological features of the tumoral specimens were characterized. Approximately 60 % of patients had invasive ductal carcinoma, and 80 % were ER positive; 65 % were PR positive; and 65 % were HER2 negative. The segments with confirmed cancer had significantly less amounts of total lipids as compared with the corresponding grossly normal or interface tissues. The fatty acid profile in cancer tissue was significantly different from that in other tissues. Fatty acid composition of five classes of phospholipids revealed the variations between cancer tissue and the other two segments. A transition of changes in fatty acid composition in these fractions of phospholipids was observed. The interface tissue had intermediate amounts of several fatty acids including palmitic acid, stearic acid, and arachidonic acid. Interestingly, we observed significantly higher amounts of the n-3 fatty acid DHA in cancer tissue as compared to the other two tissues. Data from this study will provide evidence that biochemical changes particularly phospholipid composition may take place well in advance prior to morphological changes. Should this theory be confirmed by larger studies, deviation of phospholipid composition from normal values can be used as markers of susceptibility of tissue to cancer development.