Efficient synthesis of thioglycosylated kojic acid by s-glycosyl isothiouronium salts
Efficient synthesis of thioglycosylated kojic acid by s-glycosyl isothiouronium salts
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s-糖基异硫脲盐高效合成硫代糖基化曲酸
DOI：
10.1080/07328303.2016.1261881
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发表时间：
2016-09
影响因子：
1
通讯作者：
Peng Shen
中科院分区：
文献类型：
--
作者：
zhimeng wu;Aijie Cao;Wenzhang Ding;Tao Zhu;Peng Shen
GRAPHICAL ABSTRACT ABSTRACT In this study, 7-S-glycosides of kojic acid were designed and synthesized as mimics of its 7-O-glycosides to improve its water solubility and metabolic stability. To achieve this synthesis, a one-pot approach involving S-glycosyl isothiouronium salts generated in situ as key intermediates was developed by using 7-chloro-kojic acid as the alkylation reagent. A series of water soluble 7-S-glycosides of kojic acid, incorporating monosaccharides and disaccharides, were prepared using this protocol. Thus, this work offers a mild, convenient, and efficient approach for the synthesis of 7-S-glycosides of kojic acid in medium to good yields.
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DOI：
10.1002/chin.200225186
发表时间：
2002-06
期刊：
ChemInform
影响因子：
--
作者：
M. Adinolfi;G. Barone;Alfonso Iadonisi;M. Schiattarella
通讯作者：
M. Adinolfi;G. Barone;Alfonso Iadonisi;M. Schiattarella
影响因子：
1
作者：
Fujihira, T;Chida, M;Seno, M
通讯作者：
Seno, M
影响因子：
3.6
作者：
Bedini, Emiliano;Forte, Gianpiero;Dalla Cort, Antonella
通讯作者：
Dalla Cort, Antonella
影响因子：
3.2
作者：
Vivian L. Y. Yip;S. Withers
通讯作者：
Vivian L. Y. Yip;S. Withers
影响因子：
3.1
作者：
Gervay, J;Nguyen, TN;Hadd, MJ
通讯作者：
Hadd, MJ