Searching for novel crystal forms by in situ high-pressure crystallisation: the example of gabapentin heptahydrate
Searching for novel crystal forms by in situ high-pressure crystallisation: the example of gabapentin heptahydrate
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DOI：
10.1039/b924573a
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发表时间：
2010-01-01
期刊：
影响因子：
3.1
通讯作者：
Sowa, Heidrun
中科院分区：
文献类型：
--
作者：
Fabbiani, Francesca P. A.;Levendis, Demetrius C.;Sowa, Heidrun
GABA类似物加巴喷丁的水溶液在0.8 GPa下的高压结晶导致形成先前未知的七水合物形式，其结构已通过原位单晶X-射线衍射确定。详细描述了这种异常高度水合的小分子的结构和水框架。
High-pressure crystallisation of an aqueous solution of the GABA analogue gabapentin at 0.8 GPa resulted in the formation of a previously unknown heptahydrate form, whose structure has been determined by in situ single-crystal X-ray diffraction. The structure and water framework of this unusually highly hydrated small molecule are described in detail.