Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma
Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma
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DOI：
10.1016/j.oraloncology.2009.11.005
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发表时间：
2010-03-01
期刊：
影响因子：
4.8
通讯作者：
Wei, Fengcai
中科院分区：
文献类型：
--
作者：
Dong, Zuoqing;Liu, Shaohua;Wei, Fengcai
本研究采用免疫组化方法检测口腔鳞状细胞癌（OSCC）中Id-1的表达，探讨Id-1表达与肿瘤血管生成及临床预后的关系。Id-1蛋白在128例乳腺癌中有83例（64.8%）表达阳性。Id-1的表达与肿瘤大小（p = 0.013）、淋巴结转移（p = 0.001）、肿瘤分期（p = 0.031）和肿瘤复发（p = 0.003）显著相关。Id-1的表达与肿瘤内微血管密度（MVD）显著相关（r = 0.223，p = 0.011）。结果表明，Id-1的过度表达与肿瘤血管生成和不良的临床结局相关。(C)2009爱思唯尔有限公司保留所有权利。
We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p = 0.013), lymph node metastasis (p = 0.001), tumor stage (p = 0.031) and tumor recurrence (p = 0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r = 0.223, p = 0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome. (C) 2009 Elsevier Ltd. All rights reserved.