Solvent-free reactivity in the undergraduate organic laboratory
Solvent-free reactivity in the undergraduate organic laboratory
复制标题
本科生有机实验室的无溶剂反应
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
A. Dicks
中科院分区：
文献类型：
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作者：
A. Dicks
摘要 本综述重点介绍了自 2000 年以来在开发供学生使用的无溶剂有机反应方面取得的进展。它针对大学教师，以说明本科生实验室中可能进行的无溶剂反应的广泛范围。消除反应介质直接涉及绿色化学十二原则，是当代工业研究的焦点。实验条件易于实施，包括反应物研磨、室温搅拌、微波照射和常规加热。各种官能团的转变很容易实现。无溶剂反应通常在几分钟内完成，并且通常需要简单的后处理和纯化方案。程序是根据教育资源（主要是教学期刊和实验室手册）编写的，并尽可能强调必然的绿色实验元素。
Abstract This review highlights progress made since 2000 in the development of solvent-free organic reactions for student use. It is directed at university instructors to illustrate the broad scope of solventless reactivity possible in undergraduate laboratories. Eliminating a reaction medium directly addresses the Twelve Principles of Green Chemistry and is a focal point of contemporary industrial research. Experimental conditions are straightforward to implement and include reactant grinding, room temperature stirring, microwave irradiation, and conventional heating. A wide range of functional group transformations is easily achievable. Solvent-free reactions are often complete in a matter of minutes and routinely require simplistic work-up and purification protocols. Procedures are compiled from educational resources (primarily pedagogical journals and laboratory manuals) and corollary green experimental elements emphasized where possible.