Identity testing in cervical carcinoma in case of suspected mix-up.
Identity testing in cervical carcinoma in case of suspected mix-up.
复制标题
宫颈癌的身份测试，以防怀疑混淆。
DOI：
10.1097/00004347-200010000-00016
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
M. Höckel
中科院分区：
文献类型：
--
作者：
L. Horn;J. Edelmann;C. Hänel;U. Fischer;A. Müller;M. Höckel
组织病理学诊断是现代肿瘤学的基石。但是在任何阶段都可能发生标本混淆。一名25岁女性切除了一个1.2 cm的息肉样宫颈肿块，显示为低分化腺癌，前瞻性分期为T1b1（国际妇产科联合会IB1）。即使在根治性子宫切除术后的子宫切除标本的整个宫颈完全包埋和连续切片后，也只观察到原位腺癌，而没有观察到浸润性肿瘤。为了排除标本混淆，通过微卫星分析对石蜡包埋材料进行鉴别检测。对于这两种材料，我们在检测微卫星基因座HumTH 01、HumVWA、HumFGA、HumACTBP2、HumF13 B和HumD8S1132后确定了相同的结果。由此产生的同一性概率为99.9999%，不包括样本的混淆。存档石蜡包埋标本可用于确定身份，并可防止错误的患者进行大手术。
The histopathologic diagnosis is the cornerstone of modern oncology. But mix-ups of specimens can occur at any stage. The resection of a 1.2 cm polypoid cervical mass in a 25-year-old woman showed a poorly differentiated adenocarcinoma prospectively staged as T1b1 (International Federation of Gynecology and Obstetrics IB1). Even after complete embedding and serial sectioning of the whole cervix of the hysterectomy specimen after radical hysterectomy, only adenocarcinoma in situ, but no invasive tumor, was seen. To exclude a mix-up of the specimens, identity testing of the paraffin-embedded material was performed by microsatellite analysis. For both materials, we established identical results after testing the microsatellite loci HumTH01, HumVWA, HumFGA, HumACTBP2, HumF13B, and HumD8S1132. The resulting probability of identity came to 99.9999%, excluding a mix-up of the specimens. Archival paraffin-embedded specimens can be used to establish identity and can prevent the wrong patient from having major surgery.
F13B 基因座的四核苷酸重复。
影响因子：
14.9
作者：
Nishimura,DY;Murray,JC
通讯作者：
Murray,JC
人α纤维蛋白原基因座（FGA）的四核苷酸重复多态性。
影响因子：
3.5
作者：
Mills,KA;Even,D;Murray,JC
通讯作者：
Murray,JC