THE ROLE OF PROTEOLYTIC-ENZYMES IN CANCER INVASION AND METASTASIS
THE ROLE OF PROTEOLYTIC-ENZYMES IN CANCER INVASION AND METASTASIS
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DOI：
10.1007/bf00132746
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发表时间：
1992-05-01
影响因子：
4
通讯作者：
DUFFY, MJ
中科院分区：
文献类型：
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作者：
DUFFY, MJ
转移的产生似乎涉及许多不同的蛋白酶，包括尿激酶形式的纤溶酶原激活剂、组织蛋白酶B、组织蛋白酶D和各种金属蛋白酶。涉及这些蛋白酶在转移中的早期数据大多是间接的，并且基于动物模型的相关研究。最近的工作，使用特定的蛋白酶抑制剂和抗蛋白酶的抗体来阻止实验性转移，提供了更直接的证据表明蛋白酶在癌症扩散中发挥作用。此外，编码某些蛋白酶的基因的转染增加了受体细胞的转移表型。在人类肿瘤中，许多不同的蛋白酶也与转移潜力相关。结论是，某些蛋白酶可能是癌症的新预后标志物以及抗转移治疗的新靶点。
The production of metastasis appears to involve a number of different proteases including the urokinase form of plasminogen activator, cathepsin B, cathepsin D and various metalloproteases. Early data implicating these proteases in metastasis were mostly indirect and based on correlation studies in animal models. More recent work, using specific protease inhibitors and antibodies against proteases to block experimental metastasis, have provided more direct evidence that proteases play a role in cancer spread. In addition, transfection of genes encoding certain proteases increases the metastatic phenotype of the recipient cells. In human tumours, a number of different proteases also correlate with metastatic potential. It is concluded that certain proteases may be new prognostic markers in cancer as well as new targets for anti-metastatic therapy.