GROWTH IN-UTERO AND SERUM-CHOLESTEROL CONCENTRATIONS IN ADULT LIFE
GROWTH IN-UTERO AND SERUM-CHOLESTEROL CONCENTRATIONS IN ADULT LIFE
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DOI：
10.1136/bmj.307.6918.1524
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发表时间：
1993-12-11
影响因子：
--
通讯作者：
FALL, CHD
中科院分区：
文献类型：
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作者：
BARKER, DJP;MARTYN, CN;FALL, CHD
目的 - 观察胎儿生长速度下降是否与成年后血清胆固醇浓度升高有关。设计 - 对出生时体型已记录的男性和女性进行跟踪研究。地点 - 杰索普医院和北方总医院，谢菲尔德。受试者 - 1939-40 年间出生于杰索普医院的 219 名男性和女性。主要结果指标 - 总胆固醇、低密度脂蛋白的血清浓度 结果——出生时腹围较小的男性和女性血清中总密度脂蛋白胆固醇和低密度脂蛋白胆固醇以及载脂蛋白B的浓度升高。这与妊娠持续时间无关。腹围每增加 1 英寸（2-54 厘米），总胆固醇的血清浓度就会下降 0.25 mmol/l（95% 置信区间为 0.09 至 0.42）。血清低密度脂蛋白胆固醇的相应数值为 0.26 mmol/l（0.11 至 0.42），血清载脂蛋白 B 的相应数值为 0.04 g/l（0.02 至 0.07）。出生时较小的头围和胸围以及较短的身长均与血清低密度脂蛋白胆固醇浓度升高相关，但这种趋势在出生时腹围的同时回归中消失。出生时腹围与低密度脂蛋白胆固醇浓度之间的关联与社会阶层、当前体重、吸烟和饮酒无关。结论：成年后血清胆固醇浓度升高与妊娠后期生长受损有关，此时胎儿营养不良对肝脏生长产生不成比例的影响。肝脏生长受损可能会永久改变低密度脂蛋白胆固醇代谢。
Objective-To see whether reduced rates of fetal growth are related to raised serum cholesterol concentrations in adult life.Design-Follow up study of men and women whose size at birth had been recorded.Setting-Jessop and Northern General Hospitals, Sheffield.Subjects-219 men and women born in the Jessop Hospital during 1939-40.Main outcome measures-Serum concentrations of total cholesterol, low density lipoprotein cholesterol, and apolipoprotein B.Results-Men and women who had had a small abdominal circumference at birth had raised serum concentrations of total and low density lipoprotein cholesterol and apolipoprotein B. This was independent of the duration of gestation. Serum concentrations of total cholesterol fell by 0.25 mmol/l (95% confidence interval 0.09 to 0.42) with each 1 in (2-54 cm) increase in abdominal circumference. The corresponding figure for serum low density lipoprotein cholesterol was 0.26 mmol/l (0.11 to 0.42) and for serum apolipoprotein B 0.04 g/l (0.02 to 0.07). Small head and chest circumferences at birth and short length were each associated with raised serum low density lipoprotein cholesterol concentrations but the trends disappeared in a simultaneous regression with abdominal circumference at birth. The association between abdominal circumference at birth and low density lipoprotein cholesterol concentration was independent of social class, current body weight, cigarette smoking, and alcohol consumption.Conclusion-Raised serum cholesterol concentrations in adult life are associated with impaired growth during late gestation, when fetal undernutrition has a disproportionate effect on liver growth. Impaired liver growth may permanently alter low density lipoprotein cholesterol metabolism.