A novel process for drug encapsulation using a liquid to vapour phase change material
A novel process for drug encapsulation using a liquid to vapour phase change material
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DOI：
10.1039/b913178g
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发表时间：
2009-12
期刊：
影响因子：
3.4
通讯作者：
Ming‐Wei Chang;E. Stride;M. Edirisinghe
中科院分区：
文献类型：
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作者：
Ming‐Wei Chang;E. Stride;M. Edirisinghe
全氟化烃广泛用于制备用于医疗和制药应用的多功能胶囊。然而，它们与有机溶剂的非常低的相容性代表了在不使用对胶囊均匀性具有有害影响的表面活性剂或其它添加剂的情况下制备稳定液滴的重大挑战。本研究的目的是：首先，确定在没有加工助剂的情况下，全氟己烷（PFH）能否成功地被聚甲基倍半硅氧烷（PMSQ）包覆;其次，评估通过将悬浮液加热至全氟化碳的沸点以实现部分或全部的全氟化碳含量来控制胶囊内容物的可行性更换封装的液体。这两个目标都成功地实现了。通过CEHDA获得PFH填充的胶囊，其平均直径为1.200 nm，多分散指数为1.30%。通过改变工艺参数，可以得到平均粒径为37 nm、多分散指数为23%的微胶囊，表明该方法适用于微米级和纳米级微胶囊的制备。发现聚合物涂层的厚度与胶囊外径成比例，比例因子为1/10。通过在染料溶液中加热胶囊以蒸发PFH核并使液体能够向内扩散来实现染料（伊文思蓝）的包封。还通过比色法测量染料的随后释放速率。该方法可用于制备多组分和多功能的微米和纳米粒子。
Perfluorated hydrocarbons are widely used in the preparation of multifunctional capsules for medical and pharmaceutical applications. Their very low miscibility with organic solvents, however, represents a significant challenge for preparing stabilised droplets without using surfactants or other additives which have a deleterious effect upon capsule uniformity. The aims of this investigation were: firstly, to determine whether perfluorohexane (PFH) could be successfully encapsulated in a polymer, polymethylsilsesquioxane (PMSQ) in the absence of processing additives by using coaxial electrohydrodynamic atomisation (CEHDA); secondly, to assess the feasibility of controlling the content of the capsules by heating the suspension to the boiling point of the perfluorocarbon in order to achieve partial or total exchange of the encapsulated liquid. Both aims were successfully achieved. PFH-filled capsules were obtained viaCEHDA with a mean diameter of ∼200 nm and a polydispersity index of ∼30%. It was also found that capsules with a mean diameter of 37 nm and a polydispersity index of 23% could be obtained by altering the processing parameters, indicating this method is suitable for the preparation of both micro- and nanoscale capsules. The thickness of the polymeric coating was found to scale with the capsule outer diameter by a factor of ∼10. Encapsulation of a dye (Evans blue) was achieved by heating the capsules in the dye solution to vaporise the PFH core and enable inwards diffusion of the liquid. The rate of subsequent release of the dye was also measured viacolorimetry. This method may be useful in the preparation of multicomponent and multifunctional micro- and nanoparticles.