Hereditary renal cell carcinoma in the Eker rat: A unique animal model for the study of cancer susceptibility
Hereditary renal cell carcinoma in the Eker rat: A unique animal model for the study of cancer susceptibility
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DOI：
10.1016/0378-4274(95)03506-0
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发表时间：
1995-12-01
影响因子：
3.5
通讯作者：
Walker, CL
中科院分区：
文献类型：
--
作者：
Everitt, JI;Goldsworthy, TL;Walker, CL
一类基因，即所谓的肿瘤抑制基因或抗癌基因，最初被鉴定为负责人类癌症易感性的生殖系传递。肿瘤抑制基因在细胞水平上相对于肿瘤发生是隐性的，但通常表现为显性遗传的家族性癌症综合征，这种类型的癌症综合征在Eker大鼠中由于结节性硬化症2（Tsc 2）基因的遗传缺陷而出现。Eker大鼠家族性癌症综合征作为一种独特的动物模型，在其中研究肾小管上皮细胞致癌的分子途径，以及研究化学致癌物如何与癌症易感基因相互作用的一个有价值的工具。
A class of genes, the so-called tumor suppressor genes or anti-oncogenes, was originally identified as being responsible for germ-line transmission of cancer susceptibility in humans, Tumor suppressor genes are recessive at the cellular level with respect to oncogenesis but often manifest as dominantly inherited familial cancer syndromes, This type of cancer syndrome arises in the Eker rat due to a genetic defect in the tuberous sclerosis 2 (Tsc2) gene. The Eker rat familial cancer syndrome serves as a unique animal model in which to study the molecular pathways of renal tubular epithelial carcinogenesis as well as a valuable tool for studies that examine how chemical carcinogens interact with cancer susceptibility genes.