Alkylphospho-L-serine analogues: Synthesis of cytostatically active alkylphosphono derivatives
Alkylphospho-L-serine analogues: Synthesis of cytostatically active alkylphosphono derivatives
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DOI：
10.1016/s0960-894x(97)00301-6
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发表时间：
1997-07-08
影响因子：
2.7
通讯作者：
Langen, P
中科院分区：
文献类型：
--
作者：
Brachwitz, H;Olke, M;Langen, P
Hexadecylphosphono-L-serine (2) was synthesised by phospholipase-D-catalysed transesterification of hexadecylphosphonocholine in the presence of L-serine. The synthesis of beta-O-hexadecylphosphono-L-alanine (10) starting from N-benzyloxycarbonyl-L-serine benzyl ester is reported. The compounds 2 and 10 were found to exhibit cytostatic activity in vitro. (C) 1997 Elsevier Science Ltd.
