Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex
Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex
复制标题
细丝蛋白 A 相互作用蛋白在皮质中胼胝体投射神经元的正确定位中发挥作用
DOI：
10.1016/j.neulet.2015.11.049
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发表时间：
2016
期刊：
影响因子：
2.5
通讯作者：
Sato M.
中科院分区：
文献类型：
--
作者：
Yagi H;Oka Y;Komada M;Xie MJ;Noguchi K;Sato M.
在包括精神分裂症在内的某些精神疾病中，新皮层两个半球之间的胼胝体连接发生了改变。然而，如何以及为什么胼胝体连接受损的患者患有精神疾病仍不清楚。细丝蛋白A相互作用蛋白（Filamin A interacting protein，FILIP）通过突变与精神分裂症的发病机制有关，它与肌动蛋白结合蛋白结合并控制神经传递。由于皮质兴奋性神经元，包括胼胝体投射神经元，在发育过程中迁移到皮质板，肌动蛋白结合蛋白在迁移过程中起着至关重要的作用，我们评估了FILIP是否参与胼胝体投射神经元的发育，通过对Filip-knockout小鼠的组织学分析。在这些小鼠中，胼胝体投射神经元，特别是那些表达Plxnd 1的神经元在皮层浅层的定位受到干扰，这表明FILIP是将胼胝体投射与脑疾病的发病机制联系起来的关键分子。
The callosal connections between the two hemispheres of the neocortex are altered in certain psychiatric disorders including schizophrenia. However, how and why the callosal connection is impaired in patients suffering from psychiatric diseases remain unclear. Filamin A interacting protein (FILIP), whose alteration through mutation relates to schizophrenic pathogenesis, binds to actin-binding proteins and controls neurotransmission. Because cortical excitatory neurons, including callosal projection neurons, migrate to the cortical plate during development, with the actin-binding proteins playing crucial roles during migration, we evaluated whether FILIP is involved in the development of the callosal projection neurons by histological analysis ofFilip-knockout mice. The positioning of the callosal projection neurons, especially those expressingPlxnd1, in the superficial layer of the cortex is disturbed in these mice, which suggests that FILIP is a key molecule that links callosal projections to the pathogenesis of brain disorders.