Effects of medial and lateral caudate-putamen lesions on place- and cue-guided behaviors in the water maze: relation to thigmotaxis
Effects of medial and lateral caudate-putamen lesions on place- and cue-guided behaviors in the water maze: relation to thigmotaxis
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DOI：
10.1016/s0166-4328(98)00107-7
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发表时间：
1999-04-01
影响因子：
2.7
通讯作者：
White, NM
中科院分区：
文献类型：
--
作者：
Devan, BD;McDonald, RJ;White, NM
背内侧或背外侧尾壳核病变的大鼠和假手术对照组在水迷宫中进行标准隐藏平台（地点）任务训练。与对照组相比。在早期试验中，具有背内侧损伤而非背外侧损伤的大鼠逃到隐藏平台的速度较慢，并且在池壁附近游泳的时间明显更多（趋触性），但最终达到对照水平的表现。当平台从游泳池中移除时，所有组都表现出在训练象限中游泳和穿过平台的前位置的显著偏差。在实验的第二阶段，在不同的房间/水池中对大鼠进行可见平台（线索）训练，每天将平台移动到新的位置。大鼠背内侧，但不背外侧病变需要更多的试验，以达到标准，再次，趋触性观察到的早期试验。第三阶段在原始房间/游泳池中进行，包括位置保持试验，然后是位置提示竞争测试（即在隐藏平台的学习空间位置和新位置的可见平台之间进行选择）。背内侧病变大鼠游到可见平台的频率高于对照组，而背外侧病变大鼠游到可见平台的频率低于对照组。在最后阶段，在两个病变组的大鼠表现出略低于thigmotactic倾向比对照组在一个标准的旱地开放领域，发现不一致的假设，thigmotactic在水迷宫是由于增加恐惧或焦虑。与其他行为和解剖学研究结果一起，结果表明，背内侧尾壳核，凭借其与边缘系统和前额叶皮层区域的连接，可能介导的反应选择过程，整合认知信息与刺激反应倾向。(C)1999 Elsevier Science B. V.保留所有权利。
Rats with dorsomedial or dorsolateral caudate-putamen lesions and sham-operated controls were trained on the standard hidden platform (place) task in the water maze. Compared to controls. rats with dorsomedial, but not dorsolateral lesions were slower to escape to the hidden platform and spent significantly more time swimming near the wall of the pool (thigmotaxis) on the early trials, but eventually achieved control levels of performance. When the platform was removed from the pool, all groups exhibited a significant bias for swimming in the training quadrans and crossing the former location of the platform. In the second phase of the experiment rats were given visible platform (cue) training in a different room/pool with the platform moved to a new location each day. Rats with dorsomedial, but not dorsolateral lesions required more trials to reach criterion; again, thigmotaxis was observed on the early trials. The third phase, carried out in the original room/pool, included a place-retention trial followed by a place-cue competition test, (i.e. a choice between the learned spatial location of the hidden platform and the visible platform in a new location). The rats with dorsomedial, but not dorsolateral lesions swam to the visible platform more frequently than the controls. In the final phase, the rats in both lesion groups exhibited slightly lower thigmotactic tendencies than controls in a standard dry-land open field, a finding inconsistent with the hypothesis that thigmotaxis in the water maze is due to increased fear or anxiety. Taken together with other behavioral and anatomical findings, the results suggest that the dorsomedial caudate-putamen, by virtue of its connections with limbic and prefrontal cortical regions, may mediate a response selection process that integrates cognitive information with stimulus-response tendencies. (C) 1999 Elsevier Science B.V. All rights reserved.