Proving Negative Selection in the Thymus
Proving Negative Selection in the Thymus
复制标题
证明胸腺中的负选择
DOI：
10.4049/jimmunol.174.7.3841
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
J. Sprent
中科院分区：
文献类型：
--
作者：
J. Sprent
今天，许多自身反应性T细胞在胸腺的个体发育过程中被破坏的想法似乎几乎是不言而喻的。然而，证明“中央耐受”或“负选择”的概念是令人惊讶的困难，并依赖于卡普尔的一项非凡的侦探工作。
Today, the idea that many self-reactive T cells are destroyed during ontogeny in the thymus seems almost self-evident. Yet proving this concept of “central tolerance,” or “negative selection,” was surprisingly difficult and depended upon a remarkable piece of detective work by the Kappler/