A historical overview of natural products in drug discovery.
A historical overview of natural products in drug discovery.
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DOI：
10.3390/metabo2020303
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发表时间：
2012-04-16
期刊：
影响因子：
4.1
通讯作者：
Roessner U
中科院分区：
文献类型：
--
作者：
Dias DA;Urban S;Roessner U
从历史上看，天然产品自古以来就被用于治疗许多疾病和疾病的民间传说。经典的天然产物化学方法使大量的生物活性次生代谢产物从陆地和海洋来源被发现。这些天然产物中的许多已经成为当前的候选药物。这篇简短的评论旨在突出具有历史意义的生物活性海洋和陆地天然产品，它们在民间传说中的用途和快速促进其发现的复制技术。此外，讨论了天然产物化学如何导致许多候选药物的鉴定;将讨论先进的联用光谱技术的应用，以帮助他们的发现，天然产物化学的未来，并最终采用代谢组学分析和去复制方法对天然产物提取物进行综合研究。
Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of these natural products have gone on to become current drug candidates. This brief review aims to highlight historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery. Furthermore a discussion of how natural product chemistry has resulted in the identification of many drug candidates; the application of advanced hyphenated spectroscopic techniques to aid in their discovery, the future of natural product chemistry and finally adopting metabolomic profiling and dereplication approaches for the comprehensive study of natural product extracts will be discussed.