Autonomic and cardiovascular effects of central neuromedin U in rats
Autonomic and cardiovascular effects of central neuromedin U in rats
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DOI：
10.1016/j.physbeh.2008.10.008
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发表时间：
2009-02
影响因子：
2.9
通讯作者：
M. Tanida;Jun Satomi;Jiao Shen;K. Nagai
中科院分区：
文献类型：
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作者：
M. Tanida;Jun Satomi;Jiao Shen;K. Nagai
以前的研究表明，神经梅毒素U(NMU)影响大鼠的心血管功能，如血压(BP)和心率(HR)。本实验观察了侧脑室注射不同剂量的NMU对乌拉坦麻醉大鼠肾交感神经活动(RSNA)和血压的影响。侧脑室注射NMU使RSNA、BP和HR升高，并呈剂量依赖关系。此外，侧脑室注射组胺能H_3受体拮抗剂硫哌丁胺和组胺能H_1受体拮抗剂苯海拉明均不能阻断NMU对RSNA、BP和HR的升高作用。此外，侧脑室注射NMU可抑制麻醉大鼠胃迷走神经活动(GVNA)和激活的棕色脂肪组织交感神经活动(BAT-SNA)，升高清醒大鼠的棕色脂肪组织温度(BAT-T)。因此，这些证据表明，NMU通过调节中枢机制影响含有RSNA、GVNA或BAT-SNA的自主神经和BP的神经活动。
Previous studies have demonstrated that neuromedin U (NMU) affects cardiovascular functions such as blood pressure (BP) or heart rate (HR) in rats. Here, we examined the effects of the lateral cerebral ventricular (ICV) injection of various doses of NMU on renal sympathetic nerve activity (RSNA) and BP in urethane-anesthetized rats. ICV injection of NMU elevated RSNA, BP and HR in a dose-dependent manner. Moreover, neither ICV pretreatment of thioperamide, an antagonist of histaminergic H3-receptor, or of diphenhydramine, an antagonist of histaminergic H1-receptor, abolished increasing effects of NMU on RSNA, BP and HR In addition, ICV injection of NMU suppressed gastric vagal nerve activity (GVNA) and activated brown adipose tissue sympathetic nerve activity (BAT-SNA) of anesthetized rats, and elevated brown adipose tissue temperature (BAT-T) of conscious rats. Thus, these evidence suggest that NMU affects neural activities of autonomic nerves containing RSNA, GVNA or BAT-SNA, and BP by mediating central mechanism.