Predictive Value of Nutritional Risk Screening 2002 and Prognostic Nutritional Index for Esophageal Cancer Patients Undergoing Definitive Radiochemotherapy
Predictive Value of Nutritional Risk Screening 2002 and Prognostic Nutritional Index for Esophageal Cancer Patients Undergoing Definitive Radiochemotherapy
复制标题
2002年营养风险筛查及预后营养指数对食管癌根治性放化疗患者的预测价值
DOI：
10.1080/01635581.2018.1470656
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发表时间：
2018-01-01
影响因子：
2.9
通讯作者：
Chen, Ming
中科院分区：
文献类型：
--
作者：
Wang, Jin;Yu, Binqi;Chen, Ming
摘要目的：本研究确定食管癌放化疗（CRT）患者预后营养因素及其与生存结局的关系。方法：97例既往行CRT治疗的食管癌患者入组研究。采用营养风险筛查2002 （NRS-2002）评估营养状况。同时记录体重、血清总蛋白、白蛋白、前白蛋白水平、红细胞、总淋巴细胞计数和血红蛋白。计算预后营养指数（PNI）。结果：从基线到放疗第6周，存在营养风险的患者比例有所增加。在单因素分析中，基线时NRS-2002截止评分≤3分与2年总生存（OS）的改善相关。治疗期间最大NRS-2002截止评分≤2分与改善的2年OS≥3相关。基线PNI或CRT≥45时的PNI与<45的2年OS改善相关。Cox回归分析显示，TNM分期、基线时NRS-2002评分、CRT第3周时PNI是影响预后的独立危险因素。结论：NRS2002评分和PNI是预测食管癌患者CRT后远期预后的简单有效的指标。
Abstract Objectives: The present study identified the prognostic nutritional factors and their relationships with survival outcome in patients with esophageal cancer treated with chemoradiotherapy (CRT). Methods: A total of 97 esophageal cancer patients previously treated with CRT were enrolled in the study. The nutritional status was assessed by Nutrition Risk Screening 2002 (NRS-2002). Weight, total serum protein, albumin, prealbumin level, red blood cell, total lymphocyte count, and hemoglobin were also recorded. The prognostic nutritional index (PNI) was calculated. Results: The proportion of patients at nutritional risk from baseline until the sixth week of radiotherapy was increased. In univariate analysis, the NRS-2002 cutoff score ≤3 at baseline was associated with improved 2-year overall survival (OS) than that ≥4. The maximum NRS-2002 cutoff score ≤2 during treatment was associated with an improved 2-year OS that ≥3. The baseline PNI or PNI at the end of CRT ≥45 was associated with improved 2-year OS than that <45. Cox regression analyses revealed that the TNM stage, NRS-2002 score at baseline, and PNI at the third week of CRT were independent risk factors for prognosis. Conclusions: The NRS2002 scores and PNI are simple and useful markers for predicting the long-term outcome in patients with esophageal cancer after CRT.