Plasma cytokine profiles in elderly humans
Plasma cytokine profiles in elderly humans
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DOI：
10.1016/s0047-6374(03)00025-3
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发表时间：
2003-04-01
影响因子：
5.3
通讯作者：
Wikby, A
中科院分区：
文献类型：
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作者：
Forsey, RJ;Thompson, JM;Wikby, A
众所周知，随着年龄的增长，免疫失调经常发生，导致健康状况不佳，对许多不同疾病的易感性增加。在这项研究中，我们研究了血浆细胞因子谱，以确定衰老的免疫标志物。血浆样本来自瑞典纵向NONA研究的138名参与者（年龄分别为86岁、90岁和94岁）和18名健康的瑞典志愿者（年龄在32岁至59岁之间）。我们的研究结果显示，在老年组中，促炎细胞因子白细胞介素-6 （P < 0.0001）和可溶性细胞间粘附分子-1 （P < 0.0001）水平显著升高。抗炎细胞因子白细胞介素-10不随年龄变化，而活性（自然加工）转化生长因子- β水平在老年组显著（P < 0.0001）升高。在男性和女性之间没有观察到差异。这些数据表明，随着年龄的增长，细胞因子谱发生了可测量的变化，潜在有害分子的水平增加，这可能导致老年人的免疫改变和健康状况下降。(C) 2003爱思唯尔科学爱尔兰有限公司版权所有。
It is known that as we age, immune dysregulation often occurs, leading to failing health, and increased susceptibility to a number of different diseases. In this study we have investigated plasma cytokine profiles in order to identify immune markers of ageing. Plasma samples were obtained from 138 participants of the Swedish longitudinal NONA study (aged 86, 90 and 94 years) and 18 healthy Swedish volunteers (aged between 32 and 59 years). Our results show significantly increased levels of the pro-inflammatory cytokine interleukin-6 (P < 0.0001) and soluble intercellular adhesion molecule-1 (P < 0.0001) in the elderly group. The antiinflammatory cytokine interleukin-10 did not alter with age whereas active (naturally processed) transforming growth factor-beta levels were significantly (P < 0.0001) increased in the elderly group. No difference was observed between males and females. These data suggest that there are measurable changes in cytokine profiles with ageing with increased levels of potentially harmful molecules, which may contribute to immune alterations and declining health in the elderly population. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.