Spatial and Effector Processing in the Human Parietofrontal Network for Reaches and Saccades
Spatial and Effector Processing in the Human Parietofrontal Network for Reaches and Saccades
复制标题
DOI：
10.1152/jn.91194.2008
复制
发表时间：
2009-06-01
影响因子：
2.5
通讯作者：
Medendorp, W. P.
中科院分区：
文献类型：
--
作者：
Beurze, S. M.;de Lange, F. P.;Medendorp, W. P.
Beurze SM，de Lange FP，Toni I，Medendorp WP.人类顶叶额叶网络中的空间和效应器处理。神经生理学杂志101：3053-3062，2009年。首次发表于2009年3月25日; doi：10.1152/jn.91194.2008。人们普遍认为，顶叶和额叶皮质之间的相互作用有助于眼和手运动的视觉处理。在这里，我们使用了一个顺序指令范式在3-T功能磁共振成像测试效应器和空间信号的处理，以及它们的相互作用，作为一个运动的组成和执行在不同的阶段。受试者准备眼跳或达到两个连续的视觉指令线索，以任何顺序。一个提示指示使用哪个效应器（眼睛，右手）;另一个提示运动的空间目标（目标位置与目标位置）。在第一阶段的准备运动，提示后，无论是目标或效应信息，我们发现显着的空间目标选择性，但没有效应沿着顶额叶网络的特异性。在准备运动的第二阶段，当目标和效应器信息都可用时，我们发现参与眼和手运动规划的神经回路有很大的重叠。逐渐分布沿着这个网络，我们观察到明确的空间目标的选择性和有限的，但显着的，效应特异性。顶内沟和背侧运动前区皮层对目标位置和运动效应器都有选择性。综上所述，我们的研究结果表明，空间目标和效应器选择性的相对权重的变化沿着顶额叶网络，这取决于运动计划的状态。
Beurze SM, de Lange FP, Toni I, Medendorp WP. Spatial and effector processing in the human parietofrontal network for reaches and saccades. J Neurophysiol 101: 3053-3062, 2009. First published March 25, 2009; doi:10.1152/jn.91194.2008. It is generally accepted that interactions between parietal and frontal cortices subserve the visuomotor processing for eye and hand movements. Here, we used a sequential-instruction paradigm in 3-T functional MRI to test the processing of effector and spatial signals, as well as their interaction, as a movement is composed and executed in different stages. Subjects prepared either a saccade or a reach following two successive visual instruction cues, presented in either order. One cue instructed which effector to use (eyes, right hand); the other signaled the spatial goal (leftward vs. rightward target location) of the movement. During the first phase of the prepared movement, after cueing of either goal or effector information, we found significant spatial goal selectivity but no effector specificity along the parietofrontal network. During the second phase of the prepared movement, when both goal and effector information were available, we found a large overlap in the neural circuitry involved in the planning of eye and hand movements. Gradually distributed along this network, we observed clear spatial goal selectivity and limited, but significant, effector specificity. Regions in the intraparietal sulcus and the dorsal premotor cortex were selective to both goal location and motor effector. Taken together, our results suggest that the relative weight of spatial goal and effector selectivity changes along the parietofrontal network, depending on the status of the movement plan.