Extracellular functions of galectin-3
Extracellular functions of galectin-3
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DOI：
10.1023/b:glyc.0000014082.99675.2f
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发表时间：
2002-01-01
影响因子：
3
通讯作者：
Lukyanov, P
中科院分区：
文献类型：
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作者：
Ochieng, J;Furtak, V;Lukyanov, P
Galectin-3被怀疑自从首次描述以来，以一种新颖的方式调节细胞对细胞外基质相互作用进行调节。但是，仅在过去的8年中，研究数据的迅速积累就完全改变了我们对这种多功能蛋白的看法。它的嵌合质（由碳水化合物识别和胶原蛋白像结构域组成）以某种方式适合与多种有趣的细胞外基质蛋白相互作用，其中一些可能使其能够越过质膜，尽管缺乏适当的信号肽。现在，它已成为细胞表面信号转导事件的介体，以及肾脏发育，血管生成，神经元功能，肿瘤转移，自身免疫性疾病，内吞作用，内吞作用以及可能的胞毒性等各种细胞外过程的介体。然而，它仍然保留了其作为细胞介体/调节剂对细胞外基质粘合剂相互作用的独特位置。细胞，尤其是缺乏半乳糖素3表达的上皮细胞，与其细胞外基质相互作用较差。在这些过程中的某些过程中，它起着促粘性和抗粘附性能的矩阵蛋白质作用。
Galectin-3 has been suspected of modulating cell to extracellular matrix interactions in a novel fashion ever since it was first described. However, the rapid accumulation of research data in just the last 8 years alone has completely changed our perspective of this multifunctional protein. Its chimeric nature (consists of carbohydrate recognition and collagen like domains) somehow makes it suited to interact with a plethora of interesting extracellular matrix proteins some of which might enable it to cross the plasma membrane despite its lack of appropriate signal peptides. It is now becoming established as a mediator of signal transduction events on the cell surface as well as a mediator of a variety of extra-cellular processes such as kidney development, angiogenesis, neuronal functions, tumor metastasis, autoimmune disorders, endocytosis and possibly exocytosis. Nevertheless, it still retains its unique position as a mediator/modulator of cell to extracellular matrix adhesive interactions. Cells, particularly epithelial cells which lack galectin-3 expression, interact poorly with their extracellular matrices. In some of these processes, it functions as a matricellular protein, displaying both pro- and anti-adhesive properties.