Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol plus Water Mixtures at 298.2 K
Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol plus Water Mixtures at 298.2 K
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DOI：
10.1021/je900376r
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Jouyban, Abolghasem
中科院分区：
文献类型：
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作者：
Ali, Hany S. M.;York, Peter;Jouyban, Abolghasem
布地奈德，氢化可的松，和泼尼松龙在乙醇+水的混合物在298.2 K的实验溶解度的报告。药物的溶解度随乙醇的加入而增加，并在90%、80%和80%乙醇体积分数下达到最大值。使用Jouyban-Acree模型拟合实验数据，并使用先前训练版本的Jouyban-Acree模型和单溶剂中的溶解度数据再现溶解度，其中对于拟合模型，模型的总体平均相对偏差（OMRD）分别为5.1%、6.4%、37.7%和35.9%。用于乙醇+水混合物的训练版本，以及用于各种有机溶剂+水混合物的一般训练版本。还通过先前建立的Yalkowsky对数线性模型预测了溶解度，OMRD为53.8%。
Experimental Solubilities of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2 K are reported. The Solubility of drugs was increased with the addition of ethanol and reached file maximum values of the Volume fractions of 90 %, 80 %, and 80 % of ethanol. The Jouyban-Acree model was used to fit the experimental data, and the Solubilities were reproduced using previously trained versions of the Jouyban-Acree model and the Solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 5.1 %, 6.4 %, 37.7 %, and 35.9 %, respectively, for the fitted model, the trained version for ethanol + water mixtures, and generally trained versions for Various organic solvents + water mixtures. Solubilities were also predicted by a previously established log-linear model of Yalkowsky with the OMRD of 53.8 %.