Bio-Hybrid Cell-Based Actuators for Microsystems
Bio-Hybrid Cell-Based Actuators for Microsystems
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DOI：
10.1002/smll.201400384
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发表时间：
2014-10-15
期刊：
影响因子：
13.3
通讯作者：
Sitti, Metin
中科院分区：
文献类型：
--
作者：
Carlsen, Rika Wright;Sitti, Metin
随着我们朝着器件小型化的方向发展，以执行纳米和微米级的任务，开发新的驱动、传感和控制方法变得越来越重要。在过去的十年中，生物混合方法已被研究为一种有前途的新方法，以克服缩小机器人和其他功能设备的挑战。这些方法将生物细胞与人工组件集成，因此可以利用生物细胞的固有致动和感测功能。在这里，生物混合驱动的最新进展进行了审查，并与生物混合微系统的设计，制造和控制的挑战进行了讨论。作为一个案例研究，重点放在细菌驱动的微游泳者，这已被调查作为一个有针对性的药物输送载体的发展。最后，对这些系统的发展前景进行了展望。生物和人工组件的持续集成被设想为在未来能够以越来越小的规模执行任务，从而导致功能系统在微观尺度上的并行和分布式操作。
As we move towards the miniaturization of devices to perform tasks at the nano and microscale, it has become increasingly important to develop new methods for actuation, sensing, and control. Over the past decade, biohybrid methods have been investigated as a promising new approach to overcome the challenges of scaling down robotic and other functional devices. These methods integrate biological cells with artificial components and therefore, can take advantage of the intrinsic actuation and sensing functionalities of biological cells. Here, the recent advancements in bio-hybrid actuation are reviewed, and the challenges associated with the design, fabrication, and control of bio-hybrid microsystems are discussed. As a case study, focus is put on the development of bacteria-driven microswimmers, which has been investigated as a targeted drug delivery carrier. Finally, a future outlook for the development of these systems is provided. The continued integration of biological and artificial components is envisioned to enable the performance of tasks at a smaller and smaller scale in the future, leading to the parallel and distributed operation of functional systems at the microscale.