Cardiac Magnetic Resonance Postcontrast T1 Time Is Associated With Outcome in Patients With Heart Failure and Preserved Ejection Fraction
Cardiac Magnetic Resonance Postcontrast T1 Time Is Associated With Outcome in Patients With Heart Failure and Preserved Ejection Fraction
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DOI：
10.1161/circimaging.113.000633
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发表时间：
2013-11-01
影响因子：
7.5
通讯作者：
Bonderman, Diana
中科院分区：
文献类型：
--
作者：
Mascherbauer, Julia;Marzluf, Beatrice A.;Bonderman, Diana
射血分数保留性心力衰竭（HFPEF）的病理生理机制尚不完全清楚，但心肌细胞外基质积聚被认为起主要作用。我们的目的是估计心肌细胞外基质使用心脏磁共振T1映射和评估病理生物学/病理生理学和预后之间的关系。方法和结果疑似HFPEF患者（n=100）参加了这项前瞻性，观察性研究。在基线时进行炎症诊断试验、心脏磁共振成像（包括T1标测）和侵入性血流动力学评估。61例确诊HFPEF的患者进入纵向结局监测期（平均22.95.0个月），在此期间，16例发生心脏事件。心脏磁共振T1时间（风险比，0.99; 95%置信区间，0.98-0.99; P=0.046）、左心房面积（风险比，1.08; 95%置信区间，1.03-1.13; P
Background The underlying pathophysiology of heart failure with preserved ejection fraction (HFPEF) is incompletely understood, but myocardial extracellular matrix accumulation is thought to play a major role. Our aims were to estimate myocardial extracellular matrix using cardiac magnetic resonance T1 mapping and to assess the relationship between pathobiology/pathophysiology and prognosis.Methods and Results Patients with suspected HFPEF (n=100) were enrolled in this prospective, observational study. Confirmatory diagnostic tests, cardiac magnetic resonance imaging including T1 mapping, and invasive hemodynamic assessments were performed at baseline. Sixty-one patients with confirmed HFPEF entered a longitudinal outcome-monitoring phase (mean, 22.95.0 months), during which 16 had a cardiac event. Cardiac magnetic resonance T1 time (hazard ratio, 0.99; 95% confidence interval, 0.98-0.99; P=0.046), left atrial area (hazard ratio, 1.08; 95% confidence interval, 1.03-1.13; P