Aurora kinases: novel therapy targets in cancers.
Aurora kinases: novel therapy targets in cancers.
复制标题
极光激酶：癌症的新治疗靶点。
DOI：
10.18632/oncotarget.14893
复制
发表时间：
2017-04-04
期刊：
影响因子：
--
通讯作者：
Zheng J
中科院分区：
文献类型：
--
作者：
Tang A;Gao K;Chu L;Zhang R;Yang J;Zheng J
极光激酶（Aurora kinases）是丝氨酸/苏氨酸激酶家族，由极光激酶A（Aurora A，AURKA）、极光激酶B（Aurora B，AURKB）和极光激酶C（Aurora C，AURKC）组成，通过调节有丝分裂尤其是染色体分离过程，是细胞分裂所必需的激酶。除了调节有丝分裂外，极光激酶还参与调节减数分裂。Aurora激酶的缺失可导致细胞分裂失败并损害胚胎发育。极光激酶的过度表达或基因扩增已在许多癌症中得到阐明。越来越多的研究表明，抑制Aurora激酶可以增强化疗的效果。在过去的几十年中，开发了一系列Aurora激酶抑制剂（AKI），在体内和体外有效地抑制许多癌症的进展和生长，这表明Aurora激酶可能是一种新的治疗靶点。本文将简要介绍Aurora激酶的结构、定位及其在有丝分裂中的生理功能，并阐述Aurora激酶在肿瘤发生中的致癌作用，最后讨论AKI联合常规治疗的效果。
Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via regulating mitosis especially the process of chromosomal segregation. Besides regulating mitosis, Aurora kinases have been implicated in regulating meiosis. The deletion of Aurora kinases could lead to failure of cell division and impair the embryonic development. Overexpression or gene amplification of Aurora kinases has been clarified in a number of cancers. And a growing number of studies have demonstrated that inhibition of Aurora kinases could potentiate the effect of chemotherapies. For the past decades, a series of Aurora kinases inhibitors (AKIs) developed effectively repress the progression and growth of many cancers both in vivo and in vitro, suggesting that Aurora kinases could be a novel therapeutic target. In this review, we'll first briefly present the structure, localization and physiological functions of Aurora kinases in mitosis, then describe the oncogenic role of Aurora kinases in tumorigenesis, we shall finally discuss the outcomes of AKIs combination with conventional therapy.