Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
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DOI：
10.1038/nm1078
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发表时间：
2004-08-01
期刊：
影响因子：
82.9
通讯作者：
Dana, MR
中科院分区：
文献类型：
--
作者：
Chen, L;Hamrah, P;Dana, MR
迄今为止，还没有研究将淋巴管生成的分子调控与获得性免疫的诱导联系起来。在这里，我们表明，血管内皮生长因子受体-3（VEGFR-3）信号的阻断显着抑制角膜抗原呈递（树突状）细胞贩运引流淋巴结，诱导迟发型超敏反应和角膜移植排斥反应。因此，调节VEGFR-3的功能可能是调节外周获得性免疫的机制。
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting ( dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.