Antiepiligrin Cicatricial Pemphigoid with Autoantibodies to the Beta Subunit of Laminin 5 and Associated with Severe Laryngeal Involvement Necessitating Tracheostomy
Antiepiligrin Cicatricial Pemphigoid with Autoantibodies to the Beta Subunit of Laminin 5 and Associated with Severe Laryngeal Involvement Necessitating Tracheostomy
复制标题
具有层粘连蛋白 5 β 亚基自身抗体并与需要气管切开术的严重喉部受累相关的抗表皮素瘢痕性类天疱疮
作者：
S. Seo;Y. Kye;S. Kim;Soo
我们报告一位67岁的韩国女性，患有瘢痕性类天疱疮。患者血清中免疫沉淀的多肽与具有代表性的抗瘢痕性类天疱疮患者的血清中鉴定的多肽发生迁移，并与层粘连蛋白β3亚单位免疫印迹反应。她不仅表现为皮肤、口腔和眼部，还表现为喉部和食道受累。由于声门上狭窄严重，她不得不接受气管切开术以维持呼吸道通畅。
We report the case of a 67-year-old Korean woman with antiepiligrin cicatricial pemphigoid. The patient’s serum immunoprecipitated polypeptides that comigrated with those identified in serum from a representative patient with antiepiligrin cicatricial pemphigoid, and was reactive with the laminin β3-subunit on immunoblotting. She presented not only with cutaneous, oral and ocular, but also with laryngeal and esophageal involvement. Because the supraglottic stenosis was severe, she had to undergo tracheostomy to maintain airway patency.