The age-specific force of natural selection and biodemographic walls of death.
The age-specific force of natural selection and biodemographic walls of death.
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自然选择的年龄特定力量和生物人口统计学的死亡之墙。
DOI：
10.1073/pnas.1306656110
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发表时间：
2013
影响因子：
11.1
通讯作者：
Steinsaltz,David
中科院分区：
文献类型：
--
作者：
Wachter,KennethW;Evans,StevenN;Steinsaltz,David
W. D.汉密尔顿著名的年龄特异性自然选择力公式，以依赖线性近似为代价，否定了由于突变积累而导致的衰老死亡率预测。应用到汉密尔顿的设置突变积累的完全非线性人口模型最近开发的埃文斯，斯坦萨尔茨和瓦赫特，我们发现令人惊讶的差异。非线性相互作用在最常研究的情况下导致汉密尔顿式预测的崩溃，在其他情况下改善预测，并允许在繁殖结束之前的年龄死亡的墙壁。哈勒的遗传负荷原理有一个精确但不熟悉的概括。
W. D. Hamilton’s celebrated formula for the age-specific force of natural selection furnishes predictions for senescent mortality due to mutation accumulation, at the price of reliance on a linear approximation. Applying to Hamilton’s setting the full nonlinear demographic model for mutation accumulation recently developed by Evans, Steinsaltz, and Wachter, we find surprising differences. Nonlinear interactions cause the collapse of Hamilton-style predictions in the most commonly studied case, refine predictions in other cases, and allow walls of death at ages before the end of reproduction. Haldane’s principle for genetic load has an exact but unfamiliar generalization.