Role of vitamin D in uterine fibroid biology.
Role of vitamin D in uterine fibroid biology.
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DOI：
10.1016/j.fertnstert.2015.05.031
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发表时间：
2015-09
影响因子：
6.7
通讯作者：
Halder SK
中科院分区：
文献类型：
--
作者：
Brakta S;Diamond JS;Al-Hendy A;Diamond MP;Halder SK
详细总结体外和体内动物模型中子宫肌瘤（平滑肌瘤）的现有科学知识，并假设维生素D3作为子宫肌瘤有效、廉价、安全的长期治疗选择的潜在作用。使用PubMed检索文章来识别关于子宫肌瘤的最相关研究以及维生素D3对体内动物模型中子宫肌瘤细胞和肌瘤肿瘤生长的影响。大学研究实验室附属不孕症诊所。不适用因不适用。尽管有许多关于子宫肌瘤的出版物，但关于维生素D3在调节子宫肌瘤中所起作用的信息有限。最近大多数关于子宫肌瘤的维生素D3相关研究都是由我们小组发表的。最近的研究表明，维生素D缺乏在子宫肌瘤的发展中起着重要作用。我们最近的研究表明，维生素D3在体外可减少平滑肌瘤细胞增殖，在体内动物模型中可减少平滑肌瘤肿瘤生长。这些结果假定维生素D3作为子宫肌瘤有效、安全的非手术药物治疗选择的潜在作用。本文回顾了人类和动物研究，并揭示了了解基于维生素D的治疗选择的新可能性，以有效，安全地长期治疗子宫肌瘤。基于这些结果，可能需要对子宫肌瘤的非手术药物治疗进行维生素D3或低钙类似物帕立骨化醇的临床试验。
To provide a detailed summary of current scientific knowledge on uterine fibroids (leiomyomas) in vitro and in in vivo animal models, as well as to postulate the potential role of vitamin D3 as an effective, inexpensive, safe long-term treatment option for uterine fibroids. PubMed search articles were used to identify the most relevant studies on uterine fibroids as well as effects of vitamin D3 on uterine fibroid cells and fibroid tumor growth in in vivo animal models. University research laboratory - affiliated infertility clinic. Not applicable. None Not applicable. Despite numerous publications available on uterine fibroids, information about the role that vitamin D3 plays in the regulation of uterine fibroids are limited. Most of the recent vitamin D3-related studies on uterine fibroids were published from our group. Recent studies have demonstrated that vitamin D deficiency plays a significant role in the development of uterine fibroids. Our recent studies have demonstrated that vitamin D3 reduces leiomyoma cell proliferation in vitro, and leiomyoma tumor growth in in vivo animal models. These results postulate the potential role of vitamin D3 for an effective, safe non-surgical medical treatment option for uterine fibroids. This article reviews human and animal studies and uncover new possibilities for understanding the vitamin D-based therapeutic option for an effective, safe long-term treatment of uterine fibroids. Based on these results, a clinical trial with vitamin D3 or a hypocalcemic analog, paricalcitol may be warranted for non-surgical medical treatment of uterine fibroids.