The role of apoptosis in regulating hematopoiesis and hematopoietic stem cells
The role of apoptosis in regulating hematopoiesis and hematopoietic stem cells
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DOI：
10.1385/ir:22:2-3:83
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发表时间：
2000-01-01
影响因子：
4.4
通讯作者：
Domen, J
中科院分区：
文献类型：
--
作者：
Domen, J
细胞凋亡，或者说细胞以有序和高度调控的方式死亡的能力，对于多细胞生物的正常发育和稳态至关重要。与该过程失调有关的疾病包括自身免疫性疾病、癌症和阿尔茨海默病。细胞凋亡对于淋巴细胞发育和功能的重要性已得到广泛研究。细胞凋亡在调节早期祖细胞和干细胞区室中的作用尚不清楚。这个问题正在使用转基因小鼠模型 H2K-BCL-2 进行研究，其中所有造血细胞对细胞凋亡的抵抗力都增强。同样的转基因模型也被用来解决这样的问题：防止细胞凋亡是否可以增加全系统对致命挑战（例如辐射和化疗药物）的抵抗力。
Apoptosis, or the ability of cells to die in an orderly and highly regulated manner, is essential for normal development and homeostasis of multicellular organisms. Diseases in which deregulation of this process is implicated include autoimmune diseases, cancer and Alzheimer's disease, The importance of apoptosis for the development and function of lymphoid cells has been extensively investigated. Less clear is the role apoptosis plays in regulating early progenitor and stem cell compartments. This question is being investigated using a transgenic mouse model, H2K-BCL-2, in which all hematopoietic cells have an increased resistance to apoptosis. The same transgenic model is also being used to address the question whether protection against apoptosis can increase system-wide resistance to lethal challenges such as irradiation and chemotherapeutic agents.