Pregabalin is effective against behavioral and electrographic seizures during alcohol withdrawal
Pregabalin is effective against behavioral and electrographic seizures during alcohol withdrawal
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DOI：
10.1093/alcalc/agl029
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发表时间：
2006-07-01
影响因子：
2.8
通讯作者：
Veatch, Lynn M.
中科院分区：
文献类型：
--
作者：
Becker, Howard C.;Myrick, Hugh;Veatch, Lynn M.
目的：在多种测试情况下，普瑞巴林已被证明具有抗惊厥、镇痛和抗焦虑的特性。本研究旨在评估普瑞巴林在乙醇依赖小鼠模型中对与酒精戒断相关的中枢神经系统过度兴奋的行为和电图测量发挥抗惊厥作用的能力。方法：成年小鼠长期接触乙醇，停药后测试癫痫活动（处理引起的惊厥）的行为体征或皮层和皮层下部位记录的自发脑电图活动异常。结果：与媒介物处理的小鼠相比，停药 1 小时和 4 小时后给予普瑞巴林（50-200 mg/kg）可依赖性地降低操作引起的惊厥的严重程度。同样，普瑞巴林以剂量相关的方式降低了脑电图活动被一系列高压同步活动中断的频率。最后，普瑞巴林对反复戒断的治疗可有效阻止在媒介物处理的小鼠中观察到的戒断过敏的发展。结论：总的来说，这些结果表明普瑞巴林可能是酒精戒毒医疗管理的有效治疗剂。
Aims: Pregabalin has been shown to possess anticonvulsant, analgesic, and anxiolytic properties in a variety of testing situations. This study was designed to evaluate the ability of pregabalin to exert its anticonvulsant effects against behavioral and electrographic measures of CNS hyperexcitability associated with alcohol withdrawal in a mouse model of ethanol dependence. Methods: Adult mice were chronically exposed to ethanol and, upon withdrawal, were tested for behavioral signs of seizure activity (handling-induced convulsions) or abnormalities in spontaneous EEG activity recorded from cortical and subcortical sites. Results: Pregabalin (50-200 mg/kg) administered 1 and 4 h into withdrawal dose dependently reduced severity of handling-induced convulsions in comparison to vehicle-treated mice. Similarly, pregabalin reduced the frequency in which EEG activity was interrupted by trains of high-voltage synchronous activity in a dose-related fashion. Finally, pregabalin treatment of repeated withdrawals was effective in blocking the development of withdrawal sensitization observed in vehicle-treated mice. Conclusions: Collectively, these results suggest that pregabalin may be an effective therapeutic agent for medical management of alcohol detoxification.