Characterization of the inflammatory and immune effector cells in the lung parenchyma of patients with interstitial lung disease.
Characterization of the inflammatory and immune effector cells in the lung parenchyma of patients with interstitial lung disease.
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间质性肺疾病患者肺实质中炎症和免疫效应细胞的特征。
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
R. Crystal
中科院分区：
文献类型：
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作者：
G. Hunninghake;O. Kawanami;V. Ferrans;R. Young;W. Roberts;R. Crystal
肺间质性疾病的发病机制与肺泡结构内炎症和免疫效应细胞（肺泡炎）的数量、类型和激活状态密切相关。为了直接表征各种间质性肺疾病肺泡炎细胞的类型和状态，我们开发了一种方法，从特发性肺纤维化（n = 9）和结节病（n = 6）患者的开放式肺活检中分离炎症和免疫效应细胞。将从这些活组织中分离的细胞与从正常肺中获得的效应细胞进行比较（n = 3）。正常肺的效应细胞群包括肺泡巨噬细胞（84±17%）、淋巴细胞（16±4%）和罕见的多形核白细胞（<1%）；其中t淋巴细胞占73±4%，活化t淋巴细胞占7±2%，b淋巴细胞占9±2%。相反，特发性肺纤维化肺泡炎的一个特征性特征是…
The pathogenesis of the interstitial lung disorders is intimately related to the number, type, and state of activation of inflammatory and immune effector cells (the alveolitis) within the alveolar structures. To directly characterize the type and status of the cells comprising the alveolitis of various interstitial lung disorders, a method was developed to isolate inflammatory and immune effector cells from open lung biopsies of patients with idiopathic pulmonary fibrosis (n = 9) and sarcoidosis (n = 6). The cells isolated from these biopsies were compared with effector cells obtained from normal lung (n = 3). The effector cell populations in normal lung contained alveolar macrophages (84 ± 17%), lymphocytes (16 ± 4%), and rare polymorphonuclear leukocytes (<1%); of the lymphocytes present, 73 ± 4% were T-lymphocytes, 7 ± 2% were “activated” T-lymphocytes, and 9 ± 2% were B-lymphocytes. In contrast, a characteristic feature of the alveolitis of idiopathic pulmonary fibrosis was the presence of increased ...