Free-water metrics in medial temporal lobe white matter tract projections relate to longitudinal cognitive decline
Free-water metrics in medial temporal lobe white matter tract projections relate to longitudinal cognitive decline
复制标题
DOI：
10.1016/j.neurobiolaging.2020.05.001
复制
发表时间：
2020-10-01
影响因子：
4.2
通讯作者：
Hohman, Timothy J.
中科院分区：
文献类型：
--
作者：
Archer, Derek B.;Moore, Elizabeth E.;Hohman, Timothy J.
虽然海马体积长期以来一直是认知能力下降的预测因子，但对白色物质的弥散磁共振成像研究也显示了类似的关系。尽管如此，灰质和白色物质的相互作用是否能预测认知障碍和纵向衰退仍不清楚。在这里，我们调查是否自由水（FW）和FW校正分数各向异性（FAT）内侧颞叶白色物质束提供有意义的贡献，认知和认知能力下降超出海马体积。使用来自范德比尔特记忆与衰老项目（n = 319）的数据，我们发现FW与基线记忆和执行功能相关，超出了海马体积和其他合并症。纵向分析表明，海马体积和下纵束（p = 0.043）和扣带束（p = 0.025）脂肪的记忆力下降和穹窿脂肪（p = 0.025）在执行功能下降显着的相互作用。结果表明，FW指标的白色物质在认知能力下降中具有独特的作用，并应包括在老龄化，脑血管疾病和阿尔茨海默病的理论模型。(C)2020爱思唯尔公司All rights reserved.
Although hippocampal volume has served as a long-standing predictor of cognitive decline, diffusion magnetic resonance imaging studies of white matter have shown similar relationships. Still, it remains unclear if gray matter and white matter interact to predict cognitive impairment and longitudinal decline. Here, we investigate whether free-water (FW) and FW-corrected fractional anisotropy (FAT) within medial temporal lobe white matter tracts provides meaningful contribution to cognition and cognitive decline beyond hippocampal volume. Using data from the Vanderbilt Memory & Aging Project (n = 319), we found that FW was associated with baseline memory and executive function beyond that of hippocampal volume and other comorbidities. Longitudinal analyses demonstrated significant interactions of hippocampal volume and inferior longitudinal fasciculus (p = 0.043) and cingulum bundle (p = 0.025) FAT on memory decline and with fornix FAT (p = 0.025) on decline in executive function. Results suggest that FW metrics of white matter have a unique role in cognitive decline and should be included in theoretical models of aging, cerebrovascular disease, and Alzheimer's disease. (C) 2020 Elsevier Inc. All rights reserved.